CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020218
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Monoacylglycerol lipase ABHD6 
Protein Synonyms/Alias
 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6 
Gene Name
 ABHD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
126LSIDGQVKRIHQFVEubiquitination[1, 2, 3]
223LCSYVRFKVPQQILQubiquitination[3, 4]
267HQNMDKIKVPTQIIWubiquitination[3]
335HNTDNNKKLD*****ubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity). 
Sequence Annotation
 ACT_SITE 148 148 Charge relay system (By similarity).
 ACT_SITE 278 278 Charge relay system (By similarity).
 ACT_SITE 306 306 Charge relay system (By similarity).  
Keyword
 Complete proteome; Hydrolase; Membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 337 AA 
Protein Sequence
MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYVHHEDYQF 60
CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS 120
IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG GQVAGVYAAY YPSDVSSLCL VCPAGLQYST 180
DNQFVQRLKE LQGSAAVEKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN 240
NFYRKLFLEI VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL 300
LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD 337 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0047372; F:acylglycerol lipase activity; IEA:EC.
 GO:0060292; P:long term synaptic depression; IEA:Compara.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:2000124; P:regulation of endocannabinoid signaling pathway; IEA:Compara. 
Interpro
 IPR000073; AB_hydrolase_1.
 IPR000639; Epox_hydrolase-like. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR00111; ABHYDROLASE.
 PR00412; EPOXHYDRLASE.