CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-038474
UniProt Accession
E9Q5B5_MOUSE
;
E9Q5B5
Genbank Protein ID
AC116811
Genbank Nucleotide ID
Protein Name
Hexokinase-2
Protein Synonyms/Alias
Gene Name
Hk2
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Lysine Modification
Position
Peptide
Type
References
423
RSEDGSG
K
GAAMVTA
ubiquitination
[1]
460
HEQLLEV
K
RRMKVEM
ubiquitination
[1]
710
ELSLNPG
K
QRFEKMI
ubiquitination
[1]
735
NILIDFT
K
RGLLFRG
ubiquitination
[1]
Reference
[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [
PMID: 22790023
]
Functional Description
Sequence Annotation
Keyword
ATP-binding; Complete proteome; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
889 AA
Protein Sequence
MRLSDETLLE ISRRFRKEME KGLGATTHPT AAVKMLPTFV RSTPDGTEHG EFLALDLGGT 60
NFRVLRVRVT DNGLQRVEME NQIYAIPEDI MRGSGTQLFD HIAECLANFM DKLQIKEKKL 120
PLGFTFSFPC HQTKLDESFL VSWTKGFKSS GVEGRDVVDL IRKAIQRRGD FDIDIVAVVN 180
DTVGTMMTCG YDDQNCEIGL IVGTGSNACY MEEMRHIDMV EGDEGRMCIN MEWGAFGDDG 240
TLNDIRTEFD REIDMGSLNP GKQLFEKMIS GMYMGELVRL ILVKMAKAEL LFQGKLSPEL 300
LTTGSFETKD VSDIEDDKDG IQKAYQILVR LGLSPLQEDC VATHRICQIV STRSASLCAA 360
TLAAVLWRIK ENKGEERLRS TIGVDGSVYK KHPHFAKRLH KAVRRLVPDC DVRFLRSEDG 420
SGKGAAMVTA VAYRLADQHR ARQKTLESLK LSHEQLLEVK RRMKVEMEQG LSKETHEAAP 480
VKMLPTYVCA TPDGTEKGDF LALDLGGTNF RVLLVRVRNG KRRGVEMHNK IYSIPQEVMH 540
GTGEELFDHI VQCIADFLEY MGMKGVSLPL GFTFSFPCQQ NSLDQSILLK WTKGFKASGC 600
EGEDVVTLLK EAIRRREEFD LDVVAVVNDT VGTMMTCGYE DPHCEVGLIV GTGSNACYME 660
EMRNVELVDG EEGRMCVNME WGAFGDNGCL DDLRTVFDVA VDELSLNPGK QRFEKMISGM 720
YLGEIVRNIL IDFTKRGLLF RGRISERLKT RGIFETKFLS QIESDCLALL QVRAILRHLG 780
LESTCDDSII VKEVCTVVAR RAAQLCGAGM AAVVDKIREN RGLDNLKVTV GVDGTLYKLH 840
PHFAKVMHET VRDLAPKCDV SFLESEDGSG KGAALITAVA CRIREAGQR 889
Gene Ontology
GO:0005829
; C:cytosol; IBA:RefGenome.
GO:0005741
; C:mitochondrial outer membrane; IEA:Compara.
GO:0005739
; C:mitochondrion; IDA:MGI.
GO:0005524
; F:ATP binding; IEA:UniProtKB-KW.
GO:0008865
; F:fructokinase activity; IBA:RefGenome.
GO:0004340
; F:glucokinase activity; IBA:RefGenome.
GO:0005536
; F:glucose binding; IEA:Compara.
GO:0019158
; F:mannokinase activity; IBA:RefGenome.
GO:0008637
; P:apoptotic mitochondrial changes; IGI:MGI.
GO:0001678
; P:cellular glucose homeostasis; IBA:RefGenome.
GO:0006096
; P:glycolysis; IBA:RefGenome.
GO:0007595
; P:lactation; IEA:Compara.
GO:0046324
; P:regulation of glucose import; IMP:MGI.
Interpro
IPR001312
; Hexokinase.
IPR022673
; Hexokinase_C.
IPR019807
; Hexokinase_CS.
IPR022672
; Hexokinase_N.
Pfam
PF00349
; Hexokinase_1
PF03727
; Hexokinase_2
SMART
PROSITE
PS00378
; HEXOKINASES
PRINTS
PR00475
; HEXOKINASE.