UniProt Accession

 LYSC_CHICK; P00698; Q90884 

Genbank Protein ID

 J00885; V00428; AF410481; M10640 

Genbank Nucleotide ID

 AAA48943.1; CAA23711.1; AAL69327.1; AAA48944.1 

Protein Name

 Lysozyme C 

Protein Synonyms/Alias

 1,4-beta-N-acetylmuramidase C; Allergen Gal d IV; Gal d 4 

Gene Name

 LYZ 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Gallus gallus (Chicken) 

NCBI Taxa ID

 9031 

Lysine Modification

Position	Peptide	Type	References
19	LPLAALGKVFGRCEL	acetylation	[1]
19	LPLAALGKVFGRCEL	glycation	[2, 3]
31	CELAAAMKRHGLDNY	acetylation	[1]
31	CELAAAMKRHGLDNY	glycation	[2, 4]
51	GNWVCAAKFESNFNT	acetylation	[5, 6]
51	GNWVCAAKFESNFNT	glycation	[2, 3, 4]
114	TASVNCAKKIVSDGN	acetylation	[1, 6]
114	TASVNCAKKIVSDGN	glycation	[2, 3]
115	ASVNCAKKIVSDGNG	acetylation	[1, 6]
115	ASVNCAKKIVSDGNG	glycation	[2, 7]
134	VAWRNRCKGTDVQAW	acetylation	[1]
134	VAWRNRCKGTDVQAW	glycation	[2, 3, 4]

Reference

 [1] Effects of chemical modification of lysine residues on the sweetness of lysozyme.
 Masuda T, Ide N, Kitabatake N.
 Chem Senses. 2005 Mar;30(3):253-64. [PMID: 15741597]
 [2] Effect of limited solid-state glycation on the conformation of lysozyme by ESI-MSMS peptide mapping and molecular modeling.
 Yeboah FK, Alli I, Yaylayan VA, Yasuo K, Chowdhury SF, Purisima EO.
 Bioconjug Chem. 2004 Jan-Feb;15(1):27-34. [PMID: 14733580]
 [3] Determination of dideoxyosone precursors of AGEs in human lens proteins.
 Linetsky M, Kaid Johar SR, Meltretter J, Padmanabha S, Parmar T, Vasavada AR, Pischetsrieder M, Nagaraj RH.
 Arch Biochem Biophys. 2011 Oct;514(1-2):16-26. [PMID: 21820400]
 [4] Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues.
 Chetyrkin S, Mathis M, Pedchenko V, Sanchez OA, McDonald WH, Hachey DL, Madu H, Stec D, Hudson B, Voziyan P.
 Biochemistry. 2011 Jul 12;50(27):6102-12. [PMID: 21661747]
 [5] Titration study of acetylated lysozyme.
 Okuda T, Sugai S.
 J Biochem. 1975 Dec;78(6):1241-6. [PMID: 5421]
 [6] Molecular characterization of monovalent and multivalent hapten-protein conjugates for analysis of the antigen--antibody interaction.
 Oda M, Sato-Nakamura N, Azuma T.
 Anal Biochem. 2004 Oct 15;333(2):365-71. [PMID: 15450814]
 [7] Site-specific quantitative evaluation of the protein glycation product N6-(2,3-dihydroxy-5,6-dioxohexyl)-L-lysinate by LC-(ESI)MS peptide mapping: evidence for its key role in AGE formation.
 Biemel KM, Lederer MO.
 Bioconjug Chem. 2003 May-Jun;14(3):619-28. [PMID: 12757388] 

Functional Description

 Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. 

Sequence Annotation

 ACT_SITE 53 53
 ACT_SITE 70 70
 BINDING 119 119 Substrate.
 DISULFID 24 145
 DISULFID 48 133
 DISULFID 82 98
 DISULFID 94 112  

Keyword

 3D-structure; Allergen; Antimicrobial; Bacteriolytic enzyme; Complete proteome; Direct protein sequencing; Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:AgBase.
 GO:0003796; F:lysozyme activity; IEA:EC.
 GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
 GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
 GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. 

Interpro

 IPR001916; Glyco_hydro_22.
 IPR019799; Glyco_hydro_22_CS.
 IPR000974; Glyco_hydro_22_lys.
 IPR023346; Lysozyme-like_dom. 

Pfam

 PF00062; Lys 

SMART

 SM00263; LYZ1 

PROSITE

 PS00128; LACTALBUMIN_LYSOZYME_1
 PS51348; LACTALBUMIN_LYSOZYME_2 

PRINTS

 PR00137; LYSOZYME.
 PR00135; LYZLACT.