CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015924
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial antiviral-signaling protein 
Protein Synonyms/Alias
 MAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISA 
Gene Name
 MAVS 
Gene Synonyms/Alias
 IPS1; KIAA1271; VISA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
362RAGMVPSKVPTSMVLubiquitination[1]
461GPEENEYKSEGTFGIubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. 
Sequence Annotation
 DOMAIN 10 77 CARD.
 REGION 10 77 Required for interaction with NLRX1.
 REGION 143 147 Interaction with TRAF2.
 REGION 153 158 Interaction with TRAF6.
 REGION 455 460 Interaction with TRAF6.
 MOD_RES 147 147 Phosphothreonine (By similarity).
 MOD_RES 152 152 Phosphoserine.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 233 233 Phosphoserine.
 MOD_RES 234 234 Phosphothreonine.
 MOD_RES 253 253 Phosphoserine.
 MOD_RES 258 258 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Antiviral defense; Complete proteome; Host-virus interaction; Immunity; Innate immunity; Membrane; Mitochondrion; Mitochondrion outer membrane; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 540 AA 
Protein Sequence
MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN 60
TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP 120
TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES 180
SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL 240
PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT 300
TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP 360
SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK 420
PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE 480
GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH 540 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IDA:BHF-UCL.
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0002218; P:activation of innate immune response; IMP:BHF-UCL.
 GO:0071360; P:cellular response to exogenous dsRNA; IMP:BHF-UCL.
 GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
 GO:0051607; P:defense response to virus; IDA:UniProtKB.
 GO:0045087; P:innate immune response; IMP:UniProtKB.
 GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.
 GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
 GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IDA:BHF-UCL.
 GO:0002230; P:positive regulation of defense response to virus by host; IMP:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0032727; P:positive regulation of interferon-alpha production; IMP:UniProtKB.
 GO:0032728; P:positive regulation of interferon-beta production; IMP:UniProtKB.
 GO:0032757; P:positive regulation of interleukin-8 production; IDA:BHF-UCL.
 GO:0071660; P:positive regulation of IP-10 production; IDA:BHF-UCL.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IDA:BHF-UCL.
 GO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0042993; P:positive regulation of transcription factor import into nucleus; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL.
 GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IDA:UniProtKB.
 GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR026148; Mt_antiviral_sig_pro. 
Pfam
  
SMART
  
PROSITE
 PS50209; CARD 
PRINTS