| Tag | Content |
|---|
| CPLM ID | CPLM-023831 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WASH complex subunit FAM21C |
Protein Synonyms/Alias | Vaccinia virus penetration factor; VPEF |
Gene Name | FAM21C |
Gene Synonyms/Alias | KIAA0592 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 110 | EVEEPVLKAEAEKTE | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells. |
Sequence Annotation | MOD_RES 539 539 Phosphoserine.
MOD_RES 907 907 Phosphoserine. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Endosome; Membrane; Phosphoprotein; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1318 AA |
Protein Sequence | MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 60
IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 120
TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 180
DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 240
EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 300
AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 360
FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 420
AASVPSLKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA 480
DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD 540
EEDSEDLFSS QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 600
EKAKASELSK KKASALLFSS DEEWNIPASQ THLASDSRSK GEPRDSGTLQ SQEAKAVKKT 660
SLFEEDKEDD LFAIAKDSQK KTQRVSLLFE DDVDSGGSLF GSPPTSVPPA TKKKETVSEA 720
PPLLFSDEEE KEAQLGVKSV DKKVESAKES LKFGRTDVAE SEKEGLLTRS AQETVKHSDL 780
FSSSSPWDKG TKPRTKTVLS LFDEEEDKME DQNIIQAPQK EVGKGCDPDA HPKSTGVFQD 840
EELLFSHKLQ KDNDPDVDLF AGTKKTKLLE PSVGSLFGDD EDDDLFSSAK SQPLVQEKKR 900
VVKKDHSVNS FKNQKHPESI QGSKEKGIWK PETPQANLAI NPAALLPTAA SQISEVKPVL 960
PELAFPSSEH RRSHGLESVP VLPGSGEAGV SFDLPAQADT LHSANKSRVK MRGKRRPQTR 1020
AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL RAASGEDSTE EALAAAAAPW 1080
EGGPVPGVDT SPFAKSLGHS RGEADLFDSG DIFSTGTGSQ SVERTKPKAK IAENPANPPV 1140
GGKAKSPMFP ALGEASSDDD LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS 1200
QQDVILTTQD IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK 1260
KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD PLNAFGGQ 1318 |
Gene Ontology | GO:0005769; C:early endosome; IDA:UniProtKB. GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0071203; C:WASH complex; IDA:UniProtKB. GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |