| Tag | Content |
|---|
| CPLM ID | CPLM-014407 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription termination factor 1 |
Protein Synonyms/Alias | TTF-1; RNA polymerase I termination factor; Transcription termination factor I; TTF-I; mTFF-I |
Gene Name | Ttf1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 518 | KFSAKENKQIEKNVQ | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
Sequence Annotation | DOMAIN 585 634 Myb-like 1.
DOMAIN 634 718 Myb-like 2.
REGION 1 210 N-terminal region (NRD).
MOD_RES 227 227 Phosphoserine (By similarity).
MOD_RES 375 375 Phosphoserine (By similarity).
MOD_RES 451 451 Phosphoserine (By similarity).
MOD_RES 457 457 Phosphoserine.
MOD_RES 460 460 Phosphoserine.
MOD_RES 845 845 Phosphoserine (By similarity). |
Keyword | Complete proteome; Direct protein sequencing; DNA replication inhibitor; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Transcription termination. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 859 AA |
Protein Sequence | MKGGTSKFKT HTETLYKKKK WSSVSEKRPQ KCPSQCLESK QPQVSVLGKR RRASQTPAQE 60
TLESEWPQKA KRKKRRREPQ TPAQETLESE WPQKAKKKKR RGEPQTPTQE SLESEQPPVS 120
LLGKRRRESQ TPAQENSESE QPRKAKRRRK KRKGSQQPTS SLLKTPETFL KAKKTTSAHK 180
KKKNSVLEVD METGIILVDK ENMENLLETS RKDVDIVYVD MSKGQRSAKV RETGELPAAK 240
PQEHGCRELL GDVRSRKKQK HLQKVAPWDV VQGSQPESIS LPPSEPLSSE DLEGKSTEAA 300
VFCKKKSKKN VFRSQELEPI PDSLDDSETI SERLDSTHHG GAVGAGEECE STKESHSIKK 360
KSKKKKHKSV ALATSSDSAS VTDSKAKNAL VDSSEGSGAV REEDVDHRPA EAEAQACSTE 420
KHREAMQRLE PTHEEESNSE SASNSAARHI SEDRRESDDS DVDLGSAVRQ LREFIPDIQE 480
RAATTIRRMY RDDLGRFKEF KAQGVAIRFG KFSAKENKQI EKNVQDFLSL TGIESADKLL 540
YTDRYPEEKT LITNLKRKHA FRLHIGKGIA RPWKLVYYRA KKIFDVNNYK GRYNEEDTKK 600
LKAYHSLHGN DWKKIGAMVA RSSLSVALKF SQIGGTRNQG AWSKAETQRL IKAVEDVILK 660
KMSPQELREL DSKLQEDPEG RLSIVREKLY KGISWVEVEA RVETRNWMQC KSKWTEILTK 720
RMTHGGFVYR GVNALQAKIT LIERLYELNV NDANEIDWED LASAIGDVPP PFVQAKFYKL 780
KAACVPFWQK KTFPEIIDYL YKNSLPLLKE KLDKKMKKKD GQIQTPAAPK QDFLFKDIFH 840
CDDDSDEGSP EEPSASDVQ 859 |
Gene Ontology | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:MGI. GO:0003682; F:chromatin binding; IDA:MGI. GO:0003677; F:DNA binding; IDA:MGI. GO:0006338; P:chromatin remodeling; IDA:MGI. GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006363; P:termination of RNA polymerase I transcription; IDA:MGI. GO:0006361; P:transcription initiation from RNA polymerase I promoter; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |