Tag | Content |
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CPLM ID | CPLM-013520 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DDB1- and CUL4-associated factor 6 |
Protein Synonyms/Alias | Androgen receptor complex-associated protein; ARCAP; IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein; NRIP |
Gene Name | DCAF6 |
Gene Synonyms/Alias | IQWD1; MSTP055 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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626 | SASSEKAKEPETSDQ | ubiquitination | [1] | 714 | FRRRKERKEMEELDT | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. |
Sequence Annotation | REPEAT 49 88 WD 1. REPEAT 92 133 WD 2. REPEAT 139 179 WD 3. REPEAT 189 229 WD 4. REPEAT 251 290 WD 5. DOMAIN 676 705 IQ. REPEAT 718 756 WD 6. REPEAT 759 798 WD 7. MOD_RES 336 336 Phosphoserine. MOD_RES 649 649 Phosphoserine. MOD_RES 654 654 Phosphothreonine. MOD_RES 657 657 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 860 AA |
Protein Sequence | MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN 60 DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTNDKQ IVSCSGDGVI 120 FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE 180 DCKDDILINC RRAATSVAIC PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM 240 VARFIPSHLN NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE 300 ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS RWFEEASEVA 360 QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME VDTPAEQFLQ PSTSSTMSAQ 420 AHSTSSPTES PHSTPLLSSP DSEQRQSVEA SGHHTHHQSD SPSSVVNKQL GSMSLDEQQD 480 NNNEKLSPKP GTGEPVLSLH YSTEGTTTST IKLNFTDEWS SIASSSRGIG SHCKSEGQEE 540 SFVPQSSVQP PEGDSETKAP EESSEDVTKY QEGVSAENPV ENHINITQSD KFTAKPLDSN 600 SGERNDLNLD RSCGVPEESA SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA 660 HEETSTRDSA LQDTDDSDDD PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD 720 TLNIRRPLVK MVYKGHRNSR TMIKEANFWG ANFVMSGSDC GHIFIWDRHT AEHLMLLEAD 780 NHVVNCLQPH PFDPILASSG IDYDIKIWSP LEESRIFNRK LADEVITRNE LMLEETRNTI 840 TVPASFMLRM LASLNHIRAD RLEGDRSEGS GQENENEDEE 880 |
Gene Ontology | GO:0080008; C:Cul4-RING ubiquitin ligase complex; IDA:UniProtKB. GO:0005634; C:nucleus; IDA:MGI. GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:MGI. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI. GO:0016567; P:protein ubiquitination; IC:UniProtKB. |
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