| Tag | Content |
|---|
| CPLM ID | CPLM-008806 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2 |
Protein Synonyms/Alias | Synthetic lethal with MSS4 protein 2; TORC2 effector protein SLM2 |
Gene Name | SLM2 |
Gene Synonyms/Alias | LIT1; YNL047C; N2515; YNL2515P |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 578 | KLSKEKAKSNENTTE | ubiquitination | [1] | | 652 | ENVDSPRKSNQL*** | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Together with SLM1, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, inhibiting interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. |
Sequence Annotation | DOMAIN 445 555 PH.
MOTIF 640 645 PXIXIT-like, required for interaction
MOD_RES 626 626 Phosphoserine.
MOD_RES 649 649 Phosphoserine.
MOD_RES 653 653 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 656 AA |
Protein Sequence | MSYQRNSARA SLDLRSQYQQ LEGRMRSEHF NPAYQQQQQK GQNIPLSLPS SLAQRNPIPY 60
PIDAVTSDPT IPAQLNVYDH DRQNSIVDAA AGTNTTHSLN SNNIPSSQNN NINNNNINNV 120
GSFTDPSMLT LPKMSLHSHQ KQYDSNQNDP RSPLAILIPT SAQPTDVLSA RFSAWRNVIR 180
AILVYLSETA SIQDEIVRQQ LRLSHAVQFP FFSIENQYQP VSNEDKSMQK FFLPLGSGSV 240
QDLPTMLTKY HDNLASLASK SSKELTSEII PRLEDLRRDL LVKIKEIKAL QSDFKNSCNK 300
ELQQTKHLMK LFNESLKECK LGTPKSDPFL IKLQLEKQIK RQLVEENYLH EAFDNLQNSG 360
AQLESVIVME IQNGLTSYAR ILGKEAQVVF DSVISKLDST ILNKNTNLEW DSFILRNISN 420
FVPPNLPMRR FKEISYSNQN DPFTFEVKSG FLEKRSKFLK SYSRGFYVLT PSFLHEFKTP 480
DKHKFSTPLM SIPLVECTVT EHSKKTKSNS EQGKNKFILR TNSNGLIHRG HNWVFKVDSY 540
DDMIEWFGNI KALSSLPNYD DKCKYVSKVA KLSKEKAKSN ENTTESVTPQ VTNEQHTRYD 600
DVSSSNFPLN SIPKLDNLTI TNTTSSIPET NDSQIQNRVP EFYIENVDSP RKSNQL 656 |
Gene Ontology | GO:0005886; C:plasma membrane; IDA:SGD. GO:0035091; F:phosphatidylinositol binding; TAS:SGD. GO:0051017; P:actin filament bundle assembly; IGI:SGD. GO:0070941; P:eisosome assembly; IGI:SGD. GO:0016197; P:endosomal transport; IGI:SGD. GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IPI:SGD. GO:0001558; P:regulation of cell growth; IGI:SGD. GO:0031929; P:TOR signaling cascade; IPI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |