UniProt Accession

 Q69YP5_HUMAN; Q69YP5 

Genbank Protein ID

 AF123766; AK293101; AL832431; CH471059; CH471059; CH471059 

Genbank Nucleotide ID

 AAP97245.1; BAF85790.1; CAH10645.1; EAX06484.1; EAX06485.1; EAX06486.1 

Protein Name

 Guanine nucleotide-binding protein subunit gamma 

Protein Synonyms/Alias

  

Gene Name

 DKFZp762E193 

Gene Synonyms/Alias

 GNG12; hCG_1640926 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MSSKTASTNNI	ubiquitination	[1]
34	IERIKVSKASADLMS	ubiquitination	[1, 2]
64	PTSENPFKDKKTCII	ubiquitination	[1, 2]
66	SENPFKDKKTCIIL*	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). 

Sequence Annotation

  

Keyword

 Cell membrane; Lipoprotein; Membrane; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 72 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR015898; G-protein_gamma-like_dom.
 IPR001770; Gprotein-gamma. 

Pfam

 PF00631; G-gamma 

SMART

 SM00224; GGL 

PROSITE

 PS50058; G_PROTEIN_GAMMA 

PRINTS

 PR00321; GPROTEING.