CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bile acyl-CoA synthetase 
Protein Synonyms/Alias
 BACS; Bile acid-CoA ligase; BA-CoA ligase; BAL; Cholate--CoA ligase; Fatty acid transport protein 5; FATP-5; Solute carrier family 27 member 5; Very long-chain acyl-CoA synthetase-related protein; VLACS-related; VLACSR 
Gene Name
 Slc27a5 
Gene Synonyms/Alias
 Acsb; Fatp5; Vlacsr 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
285AKLRANIKWKSPAIFacetylation[1]
611GKTFDGQKLYQHVRSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. 
Sequence Annotation
 NP_BIND 292 303 AMP (Potential).  
Keyword
 ATP-binding; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Fatty acid metabolism; Ligase; Lipid metabolism; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 690 AA 
Protein Sequence
MGVWKKLTFL LLSLLLLVGL GQPLWPAATA LALRWFLGDP TCFVLLGLAF LGRPWISSWI 60
PHWLSLAAAA LTLSLLPPRP PPELRWLHKD VAFAFKLLFY GLNLRRRLNR HPPELFVDAL 120
EQQAQARPDQ VALVCTGSEG CSITNRELNA KACQAAWALK AKLKEATIQE DKGATAILVL 180
PSKSISALSV FLGLAKLGCP VAWINPHSRG MPLLHSVQSS GASVLIVDPD LQENLEEVLP 240
KLLAENIRCF YLGHSSPTPG VEALGAALDA APSDPVPAKL RANIKWKSPA IFIYTSGTTG 300
LPKPAILSHE RVIQMSNVLS FCGRTADDVV YNVLPLYHSM GLVLGVLGCL QLGATCVLAP 360
KFSASRYWAE CRQYSVTVVL YVGEVLRYLC NVPGQPEDKK HTVRFALGNG LRADVWENFQ 420
QRFGPIQIWE LYGSTEGNVG LMNYVGHCGA VGKTSCFIRM LTPLELVQFD IETAEPVRDK 480
QGFCIPVETG KPGLLLTKIR KNQPFLGYRG SQDETKRKLV ANVRQVGDLY YNTGDVLALD 540
QEGFFYFRDR LGDTFRWKGE NVSTREVEGV LSILDFLEEV NVYGVTVPGC EGKVGMAAVK 600
LAPGKTFDGQ KLYQHVRSWL PAYATPHFIR IQDSLEITNT YKLVKSQLAR EGFDVGVIAD 660
PLYILDNKAE TFRSLMPDVY QAVCEGTWKL 690 
Gene Ontology
 GO:0009925; C:basal plasma membrane; IEA:Compara.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:Compara.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0047747; F:cholate-CoA ligase activity; IDA:RGD.
 GO:0015245; F:fatty acid transporter activity; IEA:Compara.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IEA:Compara.
 GO:0006699; P:bile acid biosynthetic process; IEA:Compara.
 GO:0008206; P:bile acid metabolic process; IMP:RGD.
 GO:0046951; P:ketone body biosynthetic process; IEA:Compara.
 GO:0015911; P:plasma membrane long-chain fatty acid transport; IEA:Compara.
 GO:0006642; P:triglyceride mobilization; IEA:Compara.
 GO:0000038; P:very long-chain fatty acid metabolic process; IEA:Compara. 
Interpro
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS