CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA fragmentation factor subunit beta 
Protein Synonyms/Alias
 Caspase-activated deoxyribonuclease; CAD; Caspase-activated DNase; DNA fragmentation factor 40 kDa subunit; DFF-40 
Gene Name
 Dffb 
Gene Synonyms/Alias
 Cad 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
201SSMCHKLKSVQYNGSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. 
Sequence Annotation
 DOMAIN 7 83 CIDE-N.  
Keyword
 Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Nuclease; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 349 AA 
Protein Sequence
MCAVLPQPKC VKLRALHSSC KFGVAARSCQ ELLRKGCIRF QLPVPGSRLC MYEDGTEVTD 60
DCFPSLPNDS ELLLLTAGET WHGYVSDITR LLSVFNEPHA GVIQAARQLL SDEQAPLRQK 120
LLADLLHHVS QNITAETREQ DPSWFEGLES RFRNKSGYLR YSCESRIRGY LREVSAYISM 180
VDAAAREEYL RVLSSMCHKL KSVQYNGSYF DRGAEASSRL CTPEGWFSCQ GPFDLESCLS 240
KHSINPYGNR ESRILFSTWN LDHIIEKKRT VVPTLAEAIQ DGREVNWEYF YSLLFTAENL 300
KLVHIACHKK TTHKLQCDRS RIYRPQTGSR RKQPPRKQPP RKRPPRKRQ 349 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0004536; F:deoxyribonuclease activity; IDA:RGD.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0004516; F:nicotinate phosphoribosyltransferase activity; IEA:Compara.
 GO:0030263; P:apoptotic chromosome condensation; IEA:Compara.
 GO:0006309; P:apoptotic DNA fragmentation; IDA:RGD.
 GO:0006917; P:induction of apoptosis; IDA:RGD. 
Interpro
 IPR015311; Apoptosis_DFF40.
 IPR003508; CAD. 
Pfam
 PF02017; CIDE-N
 PF09230; DFF40 
SMART
 SM00266; CAD 
PROSITE
 PS51135; CIDE_N 
PRINTS