| Tag | Content |
|---|
| CPLM ID | CPLM-024075 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Insulin receptor substrate 4 |
Protein Synonyms/Alias | IRS-4; Phosphoprotein of 160 kDa; pp160 |
Gene Name | Irs4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 640 | DRGTKERKEAKEVRD | acetylation | [1] | | 643 | TKERKEAKEVRDMET | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. |
Sequence Annotation | DOMAIN 79 200 PH.
DOMAIN 232 336 IRS-type PTB.
REGION 650 773 CRK-binding (By similarity).
REGION 868 870 GRB2-binding (By similarity).
MOTIF 480 483 YXXM motif 1.
MOTIF 672 675 YXXM motif 2.
MOTIF 689 692 YXXM motif 3.
MOTIF 715 718 YXXM motif 4.
MOTIF 752 755 YXXM motif 5.
MOTIF 801 804 YXXM motif 6.
MOTIF 894 897 YXXM motif 7.
MOD_RES 894 894 Phosphotyrosine (By similarity). |
Keyword | Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1216 AA |
Protein Sequence | MASCSFSGHQ ALRRLRASAA AAASAALAAV ATTPLLSSGT RTALIGTGSS CPGAMWLSTA 60
TGSRSDSESE EEDLPVGDEV CKRGYLRKQK HGHRRYFVLK LETADAPARL EYYRNARKFR 120
HSVRAAAAAA EAAASGAAVP ALIPPRRVII LYQCFSVSQR ADARYRHLIA LFTQDEYFAM 180
VAENESEQES WYLLLSRLIL ESKRRRCGTL GALPDGEPAA LAAAAAAEPP FYKDVWQVVV 240
KPRGLGHRKE LSGVFRLCLT DEEVVFVRLN TEVASVVVQL LSIRRCGHSE QYFFLEVGRS 300
TVIGPGELWM QVDDSVVAQN MHELFLEKMR ALCADEYRAR CRSYSISIGA HLLTLLSTRR 360
HLGLLPLEPG GWLRRYGLEQ FCRLRAIRER EEMLFTRRFI SPREPPPPFR RGRGHLPRAR 420
RSRRAASVPP SLFRRSAPSP GRIPQPEDVP NDRAREASGS SSGNTEEKDK EGEEGNRGDC 480
IPMNNWGSGN GRGSGGGRGS SGQGSSSQGS GGRQGSGGGQ GSGGQGAGGN QCSGNGQGTA 540
GGHGSGGGGH GSGGGQRPGD GHGSGGGKNS GSGKNSDDGD RGKSVKKRSY FGKFTQSKQQ 600
QTLPPPPPPP PAAGATGGKG KSGGRFRLYF CADRGTKERK EAKEVRDMET SGGATRGPYR 660
ARAFDEDEDD PYVPMRPGVA APLACSSDYM PMAPQNSSAS TKRHSRSPFE DSRGYMMMFP 720
RVSPPPPVPS APKAPDTNKG DDSKDNDSDS DYMFMAPGAG AIPKNPPNAQ GGSSSKSWSS 780
YFSLPSPFQS SPLGQSDHSE YVPMLPGKFL GSGLHKEASF SQGTKNVSSK PSTEASFSKP 840
EDKGSSAKPS DDVPPMNKAK EPNHLSFIAK GTQVKPKPLN PTQERREAAG SRDYINIDFI 900
KRERLVLPSS AQGLPDMRGV VTDPAPTAFS GYLNVEFGVP FPNPTIRLSD LLRVLPGANS 960
IPLAGTRWPF PGSAIGSIVE AGEYIEVIFN PAMTPAMSFA DSAICYDAQT GQIYVVDPFS 1020
ECCMDVSLSP GRCSEPPPVA RLRREEAQER RRPQSRSQSL FASTRAAVSA FPTDSLDRDF 1080
PAASAVIAAP AEAPLLAVSR ALAVVSALAA APSIGDVFAG FRAAAGVDSA SARGFQPVAG 1140
AQAVREFQDL AAGWNPGALN HRARGEDLAA GAAAPPPPPR QIWVLRPQER ADSEDDDDDD 1200
DDIYVRMDFA RRDYRK 1216 |
Gene Ontology | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |