UniProt Accession

 ILVBL_HUMAN; A1L0T0; O43341; Q96F08; Q99651; Q9BWN5; Q9UEB2 

Genbank Protein ID

 U61263; AC003956; AC004794; CH471106; BC000109; BC011722; BC011761; BC126913 

Genbank Nucleotide ID

 AAC50934.1; AAB94632.1; AAC18916.1; EAW84464.1; AAH00109.1; AAH11722.1; AAH11761.1; AAI26914.1 

Protein Name

 Acetolactate synthase-like protein 

Protein Synonyms/Alias

 IlvB-like protein 

Gene Name

 ILVBL 

Gene Synonyms/Alias

 AHAS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
577	LAYTDYHKAAMGLGA	ubiquitination	[1, 2, 3]
599	ENEDQVVKVLHDAQQ	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 REGION 470 550 Thiamine pyrophosphate binding (By
 METAL 521 521 Magnesium (By similarity).
 METAL 547 547 Magnesium (By similarity).
 BINDING 98 98 Thiamine pyrophosphate (By similarity).  

Keyword

 Complete proteome; Magnesium; Membrane; Metal-binding; Polymorphism; Reference proteome; Thiamine pyrophosphate; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 632 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR012000; Thiamin_PyroP_enz_cen_dom.
 IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
 IPR000399; TPP-bd_CS.
 IPR011766; TPP_enzyme-bd_C. 

Pfam

 PF02775; TPP_enzyme_C
 PF00205; TPP_enzyme_M
 PF02776; TPP_enzyme_N 

SMART

  

PROSITE

 PS00187; TPP_ENZYMES 

PRINTS