UniProt Accession

 CDN1C_HUMAN; P49918 

Genbank Protein ID

 U22398; U48869; BC067842; D64137; D64137 

Genbank Nucleotide ID

 AAA85095.1; AAB05896.1; AAH67842.1; BAA11014.1; BAA11015.1 

Protein Name

 Cyclin-dependent kinase inhibitor 1C 

Protein Synonyms/Alias

 Cyclin-dependent kinase inhibitor p57; p57Kip2 

Gene Name

 CDKN1C 

Gene Synonyms/Alias

 KIP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
286	RKRSAPEKSSGDVPA	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. 

Sequence Annotation

 REPEAT 156 159 1.
 REPEAT 160 163 2.
 REPEAT 180 183 3.
 REPEAT 184 187 4.
 REPEAT 188 191 5.
 REPEAT 198 201 6.
 REPEAT 202 205 7.
 REPEAT 206 209 8.
 REPEAT 210 213 9.
 REGION 156 213 9 X 4 AA repeats of P-A-P-A.
 MOTIF 278 281 Nuclear localization signal (Potential).
 MOD_RES 268 268 Phosphoserine.  

Keyword

 Alternative splicing; Cell cycle; Complete proteome; Disease mutation; Nucleus; Phosphoprotein; Protein kinase inhibitor; Reference proteome; Repeat; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; TAS:ProtInc.
 GO:0007050; P:cell cycle arrest; TAS:ProtInc.
 GO:0000080; P:G1 phase of mitotic cell cycle; TAS:ProtInc.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0042551; P:neuron maturation; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IGI:UniProtKB.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:BHF-UCL.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc. 

Interpro

 IPR003175; CDI. 

Pfam

 PF02234; CDI 

SMART

  

PROSITE

  

PRINTS