UniProt Accession

 PDE12_HUMAN; Q6L8Q7; B4DTU8; Q8IYU3; Q8NDU2; Q8TE78 

Genbank Protein ID

 AB115695; AK074423; AK300374; CH471055; AL831824 

Genbank Nucleotide ID

 BAD20938.1; BAB85079.1; BAG62110.1; EAW65342.1; CAD38538.1 

Protein Name

 2',5'-phosphodiesterase 12 

Protein Synonyms/Alias

 2'-PDE; 2-PDE 

Gene Name

 PDE12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	RIATNALKGHAKAAA	ubiquitination	[1]
202	FRWYKEAKPGAAEPE	ubiquitination	[1]
427	LYPSAQEKVLQRSSV	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. 

Sequence Annotation

 MOD_RES 217 217 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 609 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 

Interpro

 IPR005135; Endo/exonuclease/phosphatase. 

Pfam

 PF03372; Exo_endo_phos 

SMART

  

PROSITE

  

PRINTS