| Tag | Content |
|---|
| CPLM ID | CPLM-009037 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gastrin/cholecystokinin type B receptor |
Protein Synonyms/Alias | CCK-B receptor; CCK-BR; Cholecystokinin-2 receptor; CCK2-R |
Gene Name | Cckbr |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 330 | GPRPNQAKLLAKKRV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). |
Sequence Annotation | LIPID 414 414 S-palmitoyl cysteine (By similarity).
CARBOHYD 7 7 N-linked (GlcNAc...) (Potential).
CARBOHYD 30 30 N-linked (GlcNAc...) (Potential).
CARBOHYD 36 36 N-linked (GlcNAc...) (Potential).
DISULFID 127 205 By similarity. |
Keyword | Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 453 AA |
Protein Sequence | MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR ELELTIRITL 60
YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF 120
IFGTVICKAV SYLMGVSVSV STLNLAAIAL ERYSAICRPL QARVWQTRSH AARVILATWL 180
LSGLLMVPYP VYTVVQPVGP RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL 240
ISRELYLGLR FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY 300
VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV CWLPVYSANT 360
WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH RRFRQACLDT CARCCPRPPR 420
ARPRPLPDED PPTPSIASLS RLSYTTISTL GPG 453 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015054; F:gastrin receptor activity; ISS:UniProtKB. GO:0048565; P:digestive tract development; IMP:MGI. GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:UniProtKB. GO:0001696; P:gastric acid secretion; IMP:MGI. GO:0048732; P:gland development; IMP:MGI. GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |