UniProt Accession

 CEBPB_MOUSE; P28033 

Genbank Protein ID

 M61007; X62600; S78572 

Genbank Nucleotide ID

 AAA37192.1; CAA44484.1 

Protein Name

 CCAAT/enhancer-binding protein beta 

Protein Synonyms/Alias

 C/EBP beta; AGP/EBP; Interleukin-6-dependent-binding protein; IL-6DBP; Liver-enriched transcriptional activator; LAP 

Gene Name

 Cebpb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	DCLAYGAKAARAAPR	acetylation	[1]
117	SLGRAGAKAAPPACF	acetylation	[1]
133	PPPPAALKAEPGFEP	sumoylation	[2]
215	APAKAKAKKTVDKLS	acetylation	[1]
216	PAKAKAKKTVDKLSD	acetylation	[1]

Reference

 [1] CCAAT/enhancer-binding protein (C/EBP) beta is acetylated at multiple lysines: acetylation of C/EBPbeta at lysine 39 modulates its ability to activate transcription.
 Ceseña TI, Cardinaux JR, Kwok R, Schwartz J.
 J Biol Chem. 2007 Jan 12;282(2):956-67. [PMID: 17110376]
 [2] Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.
 Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC.
 J Biol Chem. 2002 Oct 11;277(41):38037-44. [PMID: 12161447] 

Functional Description

 Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). 

Sequence Annotation

 DOMAIN 222 285 bZIP.
 REGION 1 22 Required for Lys-174 sumoylation (By
 REGION 226 246 Basic motif (By similarity).
 REGION 248 255 Leucine-zipper (By similarity).
 MOD_RES 188 188 Phosphothreonine; by RPS6KA1 (By
 CROSSLNK 133 133 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Activator; Complete proteome; Differentiation; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0050873; P:brown fat cell differentiation; IMP:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; IDA:MGI.
 GO:0001892; P:embryonic placenta development; IGI:MGI.
 GO:0006917; P:induction of apoptosis; IDA:MGI.
 GO:0060644; P:mammary gland epithelial cell differentiation; IMP:MGI.
 GO:0033598; P:mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0030182; P:neuron differentiation; IDA:MGI.
 GO:0045669; P:positive regulation of osteoblast differentiation; IDA:MGI.
 GO:0045408; P:regulation of interleukin-6 biosynthetic process; IDA:MGI.
 GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
 GO:0032496; P:response to lipopolysaccharide; IMP:BHF-UCL. 

Interpro

 IPR004827; bZIP.
 IPR016468; CCAAT/enhancer-binding. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS