UniProt Accession

 RSMB_YEAST; P40018; D3DLS8 

Genbank Protein ID

 U18778; AY558450; BK006939 

Genbank Nucleotide ID

 AAB64562.1; AAS56776.1; DAA07682.1 

Protein Name

 Small nuclear ribonucleoprotein-associated protein B 

Protein Synonyms/Alias

 snRNP-B; Sm protein B; Sm-B; SmB 

Gene Name

 SMB1 

Gene Synonyms/Alias

 YER029C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
3	*****MSKIQVAHSS	acetylation	[1]
138	KKPGKIAKPNTANAK	methylation	[2]
145	KPNTANAKHTSSNSR	methylation	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
 Pang CN, Gasteiger E, Wilkins MR.
 BMC Genomics. 2010 Feb 5;11:92. [PMID: 20137074] 

Functional Description

 Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. 

Sequence Annotation

 MOTIF 105 132 Nuclear localization signal (Potential).  

Keyword

 Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0005685; C:U1 snRNP; IDA:SGD.
 GO:0071004; C:U2-type prespliceosome; IDA:SGD.
 GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD.
 GO:0005682; C:U5 snRNP; IDA:SGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000398; P:mRNA splicing, via spliceosome; IPI:SGD. 

Interpro

 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS