CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005619
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cAMP-specific 3',5'-cyclic phosphodiesterase 4A 
Protein Synonyms/Alias
 DPDE2; PDE46 
Gene Name
 PDE4A 
Gene Synonyms/Alias
 DPDE2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
358NIPRFGVKTDQEELLsumoylation[1]
Reference
 [1] Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
 Li X, Vadrevu S, Dunlop A, Day J, Advant N, Troeger J, Klussmann E, Jaffrey E, Hay RT, Adams DR, Houslay MD, Baillie GS.
 Biochem J. 2010 Apr 28;428(1):55-65. [PMID: 20196770] 
Functional Description
 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. 
Sequence Annotation
 NP_BIND 433 437 cAMP (By similarity).
 REGION 330 723 Catalytic.
 ACT_SITE 433 433 Proton donor (By similarity).
 METAL 437 437 Divalent metal cation 1.
 METAL 473 473 Divalent metal cation 1.
 METAL 474 474 Divalent metal cation 1.
 METAL 474 474 Divalent metal cation 2.
 METAL 591 591 Divalent metal cation 1.
 BINDING 474 474 cAMP (By similarity).
 BINDING 591 591 cAMP (By similarity).
 BINDING 642 642 cAMP (By similarity).
 MOD_RES 152 152 Phosphoserine; by MAPKAPK2 (By
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 686 686 Phosphoserine (Probable).
 MOD_RES 688 688 Phosphoserine (Probable).
 CROSSLNK 358 358 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Alternative splicing; cAMP; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Hydrolase; Isopeptide bond; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 886 AA 
Protein Sequence
MEPPTVPSER SLSLSLPGPR EGQATLKPPP QHLWRQPRTP IRIQQRGYSD SAERAERERQ 60
PHRPIERADA MDTSDRPGLR TTRMSWPSSF HGTGTGSGGA GGGSSRRFEA ENGPTPSPGR 120
SPLDSQASPG LVLHAGAATS QRRESFLYRS DSDYDMSPKT MSRNSSVTSE AHAEDLIVTP 180
FAQVLASLRS VRSNFSLLTN VPVPSNKRSP LGGPTPVCKA TLSEETCQQL ARETLEELDW 240
CLEQLETMQT YRSVSEMASH KFKRMLNREL THLSEMSRSG NQVSEYISTT FLDKQNEVEI 300
PSPTMKEREK QQAPRPRPSQ PPPPPVPHLQ PMSQITGLKK LMHSNSLNNS NIPRFGVKTD 360
QEELLAQELE NLNKWGLNIF CVSDYAGGRS LTCIMYMIFQ ERDLLKKFRI PVDTMVTYML 420
TLEDHYHADV AYHNSLHAAD VLQSTHVLLA TPALDAVFTD LEILAALFAA AIHDVDHPGV 480
SNQFLINTNS ELALMYNDES VLENHHLAVG FKLLQEDNCD IFQNLSKRQR QSLRKMVIDM 540
VLATDMSKHM TLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLRNMVHCA DLSNPTKPLE 600
LYRQWTDRIM AEFFQQGDRE RERGMEISPM CDKHTASVEK SQVGFIDYIV HPLWETWADL 660
VHPDAQEILD TLEDNRDWYY SAIRQSPSPP PEEESRGPGH PPLPDKFQFE LTLEEEEEEE 720
ISMAQIPCTA QEALTAQGLS GVEEALDATI AWEASPAQES LEVMAQEASL EAELEAVYLT 780
QQAQSTGSAP VAPDEFSSRE EFVVAVSHSS PSALALQSPL LPAWRTLSVS EHAPGLPGLP 840
STAAEVEAQR EHQAAKRACS ACAGTFGEDT SALPAPGGGG SGGDPT 886 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016020; C:membrane; TAS:ProtInc.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006198; P:cAMP catabolic process; IMP:UniProtKB.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0043949; P:regulation of cAMP-mediated signaling; IEA:Compara.
 GO:0010738; P:regulation of protein kinase A signaling cascade; IEA:Compara.
 GO:0007608; P:sensory perception of smell; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF00233; PDEase_I 
SMART
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.