CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016852
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BCL-6 corepressor 
Protein Synonyms/Alias
 BCoR 
Gene Name
 Bcor 
Gene Synonyms/Alias
 Kiaa1575 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1464ARRLIVNKNAGETLLubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity). 
Sequence Annotation
 REPEAT 1466 1499 ANK 1.
 REPEAT 1500 1529 ANK 2.
 REPEAT 1533 1562 ANK 3.
 REGION 498 514 Interaction with BCL6 (By similarity).
 MOD_RES 336 336 Phosphoserine (By similarity).
 MOD_RES 340 340 Phosphoserine (By similarity).
 MOD_RES 365 365 Phosphoserine (By similarity).
 MOD_RES 367 367 Phosphoserine (By similarity).
 MOD_RES 392 392 N6-acetyllysine (By similarity).
 MOD_RES 423 423 Phosphoserine (By similarity).
 MOD_RES 1143 1143 Phosphoserine (By similarity).
 MOD_RES 1146 1146 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; ANK repeat; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1759 AA 
Protein Sequence
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP LSHSVVDTSG 60
AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK GREATPSSLS GLGFSSERNP 120
EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAESLGLDR PASDKQSPLN 180
INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS 240
GERFLYLPPP HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 300
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA AETYSEFHKH 360
YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG DCAQSMPGHT RKTTVQDRKD 420
GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA DASKGDHMKK MAPTVLVHSR AASGLVLSGS 480
EIPKETLSPP GNGCSIYRSE IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR 540
SSSCPRMGGT DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 600
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP AIPYPRSYLP 660
YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK PGLPYGLHTS RPEFVTYQDA 720
LGLGMVHPML IPHTPIEITK EEKPERRSRS HERARYEDPT LRSRFSEMLE ASSTKLHPEV 780
PTDKNLKPNS SWNQGKTGVK SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK 840
PSADPVIQQR REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 900
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD EAESNDGKVL 960
KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ RALQMEGLQE DSILCLPAAY 1020
CERAMMRFSE LEMKEREGSH PATKDSEVCK FSPADWERLK GNQEKKPKSV TLEEAIADQN 1080
DSERCEYSTG NKHDLFEAPE DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR 1140
KLSGDSTHTE TAVEELAEDP LKAKRRRISK DDWPEREMTN SSSNHLEDPH CNELTNLKVC 1200
IELTGLHPKK QRHLLHLRER WEQQVSAAES KPGRQSRKEV AQAVQPEVTS QGTNITEEKP 1260
GRKKAEAKGN RGWSEESLKS CDNEQGLPVL SGSPPMKSLS STNASGKKQT QPSCTPASRL 1320
PAKQQKIKES QKTDVLCTGE DEDCQAASPL QKYTDNIEKP SGKRLCKTKH LIPQESRRSL 1380
QITGDYYVEN TDTKMTVRRF RKRPEPSSDY DLSPPAKQEP KPFDRLQQLL PATQATQLPR 1440
SNSPQETTQS RPMPPEARRL IVNKNAGETL LQRAARLGYE EVVLYCLENK VCDVNHRDNA 1500
GYCALHEACA RGWLNIVRHL LEYGADVNCS AQDGTRPLHD AVENDHLEIV RLLLSYGADP 1560
TLATYSGRTI MKMTHSELME KFLTDYLNDL QGRSEDDTSG AWEFYGSSVC EPDDESGYDV 1620
LANPPGPEDP DEEEDTYSDL FEFEFAESSL LPCYNIQVSV AQGPRNWLLL SDVLKKLKMS 1680
SRIFRSNFPN LEIVTIAEAE FYRQVSTSLL FSCPKDLEAF NPESKELLDL VEFTNELQTL 1740
LGSSVEWLHP SDTGHENYW 1759 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0031519; C:PcG protein complex; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IPI:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0035518; P:histone H2A monoubiquitination; IEA:Compara.
 GO:0030502; P:negative regulation of bone mineralization; IEA:Compara.
 GO:0000415; P:negative regulation of histone H3-K36 methylation; IEA:Compara.
 GO:0051572; P:negative regulation of histone H3-K4 methylation; IEA:Compara.
 GO:0070171; P:negative regulation of tooth mineralization; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0042476; P:odontogenesis; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0065001; P:specification of axis polarity; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS