UniProt Accession

 FABPI_RAT; P02693 

Genbank Protein ID

 K01180; M35992; M18080 

Genbank Nucleotide ID

 AAA41138.1; AAA41141.1; AAA41133.1 

Protein Name

 Fatty acid-binding protein, intestinal 

Protein Synonyms/Alias

 Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP 

Gene Name

 Fabp2 

Gene Synonyms/Alias

 Fabpi 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
8	MAFDGTWKVDRNENY	acetylation	[1]
17	DRNENYEKFMEKMGI	acetylation	[1]
47	TITQEGNKFTVKESS	acetylation	[1]
93	EGNKLVGKFKRVDNG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity). 

Sequence Annotation

 BINDING 83 83 Fatty acid.
 BINDING 107 107 Fatty acid.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 132 AA 

Protein Sequence

Gene Ontology

 GO:0045179; C:apical cortex; IDA:RGD.
 GO:0005902; C:microvillus; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0005504; F:fatty acid binding; IDA:RGD.
 GO:0005324; F:long-chain fatty acid transporter activity; IDA:RGD.
 GO:0006631; P:fatty acid metabolic process; IDA:RGD.
 GO:0050892; P:intestinal absorption; IDA:RGD. 

Interpro

 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000463; Fatty_acid-bd.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 

Pfam

 PF00061; Lipocalin 

SMART

  

PROSITE

 PS00214; FABP 

PRINTS

 PR00178; FATTYACIDBP.