CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005129
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Farnesyl diphosphate synthase 
Protein Synonyms/Alias
 FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase 
Gene Name
 ispA 
Gene Synonyms/Alias
 b0421; JW0411 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
45YGALLGGKRLRPFLVacetylation[1]
200GALSAGDKGRRALPVacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 METAL 84 84 Magnesium 1.
 METAL 84 84 Magnesium 2.
 METAL 90 90 Magnesium 1.
 METAL 90 90 Magnesium 2.
 METAL 223 223 Magnesium 3.
 BINDING 45 45 Isopentenyl diphosphate.
 BINDING 48 48 Isopentenyl diphosphate.
 BINDING 77 77 Isopentenyl diphosphate.
 BINDING 95 95 Geranyl diphosphate.
 BINDING 96 96 Isopentenyl diphosphate.
 BINDING 181 181 Geranyl diphosphate.
 BINDING 182 182 Geranyl diphosphate.
 BINDING 220 220 Geranyl diphosphate.
 BINDING 237 237 Geranyl diphosphate.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Isoprene biosynthesis; Magnesium; Metal-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MDFPQQLEAC VKQANQALSR FIAPLPFQNT PVVETMQYGA LLGGKRLRPF LVYATGHMFG 60
VSTNTLDAPA AAVECIHAYS LIHDDLPAMD DDDLRRGLPT CHVKFGEANA ILAGDALQTL 120
AFSILSDADM PEVSDRDRIS MISELASASG IAGMCGGQAL DLDAEGKHVP LDALERIHRH 180
KTGALIRAAV RLGALSAGDK GRRALPVLDK YAESIGLAFQ VQDDILDVVG DTATLGKRQG 240
ADQQLGKSTY PALLGLEQAR KKARDLIDDA RQSLKQLAEQ SLDTSALEAL ADYIIQRNK 299 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004161; F:dimethylallyltranstransferase activity; IDA:EcoCyc.
 GO:0004337; F:geranyltranstransferase activity; IDA:EcoCyc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0045337; P:farnesyl diphosphate biosynthetic process; IMP:EcoCyc.
 GO:0033384; P:geranyl diphosphate biosynthetic process; IMP:EcoCyc. 
Interpro
 IPR000092; Polyprenyl_synt.
 IPR017446; Polyprenyl_synth-rel.
 IPR008949; Terpenoid_synth. 
Pfam
 PF00348; polyprenyl_synt 
SMART
  
PROSITE
 PS00723; POLYPRENYL_SYNTHASE_1
 PS00444; POLYPRENYL_SYNTHASE_2 
PRINTS