| Tag | Content |
|---|
| CPLM ID | CPLM-018609 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
Protein Synonyms/Alias | cGMP phosphodiesterase 6C |
Gene Name | Pde6c |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 461 | EMVMNLTKATPDEIS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | DOMAIN 75 224 GAF 1.
DOMAIN 256 433 GAF 2.
NP_BIND 169 172 cGMP (By similarity).
ACT_SITE 562 562 Proton donor (By similarity).
METAL 566 566 Divalent metal cation 1 (By similarity).
METAL 602 602 Divalent metal cation 1 (By similarity).
METAL 603 603 Divalent metal cation 1 (By similarity).
METAL 603 603 Divalent metal cation 2 (By similarity).
METAL 723 723 Divalent metal cation 1 (By similarity).
BINDING 97 97 cGMP (By similarity).
BINDING 116 116 cGMP (By similarity).
BINDING 176 176 cGMP (By similarity).
MOD_RES 858 858 Cysteine methyl ester (Potential).
LIPID 858 858 S-geranylgeranyl cysteine (By |
Keyword | Alternative splicing; Cell membrane; cGMP; cGMP-binding; Complete proteome; Hydrolase; Lipoprotein; Membrane; Metal-binding; Methylation; Nucleotide-binding; Prenylation; Reference proteome; Repeat; Sensory transduction; Vision. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 861 AA |
Protein Sequence | MGEISQEAVE RYLEKNPCFA KEYFDKKLRV EALGVIFKNS HAGVQTGLSL PEMTQVEESA 60
VCLELLQCMQ DEAGSAEQMA HRALQRLAQL LQADCCSMFS CRARNGIPEV ASRLLNVTPT 120
SKFEDNLVAP DREVVFPLDI GIVGWVAHVK KALNVSDVKK NSHFSDFMDK QTGYVTRNLL 180
AVPIVAGKEV LAVVMAVNKI SAPEFSKQDE EVFSKYLSFV AVALRLQHTS YLYSVESRRS 240
QILMWSANKV FEELTDVERQ FHKALYTIRT YLNCDRYSIG LLDMTKEKEF YDEWPIKLGE 300
VEPYKGPKTP DGREIIFYKI IDYILHGKEE INVIPSPPAD HWTLVSGLPT YVAENGFICN 360
MLNAPADEYF TFQKGPVDET GWVIKNVLSL PIVNKKEDIV GVATFYNRKD GKPFDEHDEH 420
ITETLTQFLG WSLLNTDTYE RVNKLESRKD IAQEMVMNLT KATPDEISSI LKFKEKLNVE 480
VIEECEERQL LAILKEDLPD PRTADLYEFC FSDFPITEHE LVKCGLRLFL EINVVEKFKV 540
PVEVLTRWMY TVRKGYRPVT YHNWRHGFNV GQTMFTLLMT GRLKKYYTDL EAFAMLAAAF 600
CHDIDHRGTN NLYQMKSTSP LARLHGTSIL ERHHLEYSKT LLQDESLNIF QNLNKRQFET 660
VIHLFEVAII ATDLALYFKK RTMFQKIVDT CEQMQSEEET IKYVTSDPTK KEVIMAMMMT 720
ACDLSAITKP WEVQSQVALL VANEFWEQGD LERTVLQQQP IPMMDRSKKD ELPKLQVGFI 780
DFVCTFVYKE FSRFHGEITP MLNGLQNNRV EWKSLAEEYE AKVKVTEEEA GKQEEEASDG 840
KAATDLGGSA EDKKSKTCLM L 861 |
Gene Ontology | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC. GO:0030553; F:cGMP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008152; P:metabolic process; IEA:GOC. GO:0007603; P:phototransduction, visible light; IMP:MGI. GO:0046549; P:retinal cone cell development; IMP:MGI. GO:0050953; P:sensory perception of light stimulus; IMP:MGI. GO:0007601; P:visual perception; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |