UniProt Accession

 MCPT2_RAT; P00770 

Genbank Protein ID

 J02712 

Genbank Nucleotide ID

 AAA66284.1 

Protein Name

 Mast cell protease 2 

Protein Synonyms/Alias

 rMCP-2; Group-specific protease; Mast cell protease II; rMCP-II 

Gene Name

 Mcpt2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
114	LHDIMLLKLEKKVEL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 This enzyme, isolated from small intestine, specifically inactivates the apo forms of a certain group of intracellular pyridoxal phosphate-requiring enzymes. It has chymotrypsin-like specificity towards small substrates. 

Sequence Annotation

 DOMAIN 21 244 Peptidase S1.
 ACT_SITE 65 65 Charge relay system.
 ACT_SITE 109 109 Charge relay system.
 ACT_SITE 202 202 Charge relay system.
 DISULFID 50 66
 DISULFID 143 208
 DISULFID 174 187  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Hydrolase; Protease; Reference proteome; Serine protease; Signal; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR009003; Trypsin-like_Pept_dom. 

Pfam

 PF00089; Trypsin 

SMART

 SM00020; Tryp_SPc 

PROSITE

 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 

PRINTS

 PR00722; CHYMOTRYPSIN.