CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015136
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 General transcription factor IIH subunit 2-like protein 
Protein Synonyms/Alias
 General transcription factor IIH polypeptide 2-like protein 
Gene Name
 GTF2H2C; GTF2H2D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23ERTWEILKEDESGSLubiquitination[1]
31EDESGSLKATIEDILubiquitination[1]
40TIEDILFKAKRKRVFubiquitination[1]
42EDILFKAKRKRVFEHubiquitination[1]
77TMEDQDLKPNRLTCTubiquitination[1]
116TKSKRAEKLTELSGNubiquitination[1]
229ILDESHYKELLTHHLubiquitination[1]
297FCPQCRAKYCELPVEubiquitination[1]
306CELPVECKICGLTLVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II (By similarity). 
Sequence Annotation
 DOMAIN 60 236 VWFA.
 ZN_FING 291 308 C4-type.
 MOD_RES 95 95 Phosphotyrosine (By similarity).  
Keyword
 Complete proteome; DNA damage; DNA repair; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH 60
LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL 120
SGNPRKHITS LKEAVDMTCH GEPSLYNSLS MAMQTLKHMP GHTSREVLII FSSLTTCDPS 180
NIYDLIKTLK AAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHLSPPP 240
ASSSSECSLI RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE 300
LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG ELKDQHVYVC 360
AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV 395 
Gene Ontology
 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007198; Ssl1-like.
 IPR004595; TFIIH_C1-like_dom.
 IPR012170; TFIIH_SSL1/p44.
 IPR002035; VWF_A.
 IPR007087; Znf_C2H2. 
Pfam
 PF07975; C1_4
 PF04056; Ssl1 
SMART
 SM01047; C1_4
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS