UniProt Accession

 CP2AC_MOUSE; P56593; Q8VCW9 

Genbank Protein ID

 L06463; CH466593; BC018356; BC094017 

Genbank Nucleotide ID

 EDL24208.1; AAH18356.1; AAH94017.1 

Protein Name

 Cytochrome P450 2A12 

Protein Synonyms/Alias

 CYPIIA12; Steroid hormones 7-alpha-hydroxylase; Testosterone 7-alpha-hydroxylase 

Gene Name

 Cyp2a12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
31	WQQKIRGKLPPGPIP	ubiquitination	[1]
51	NYLQLNRKDVYSSIT	ubiquitination	[1]
87	LYGYDAVKEALVDHA	ubiquitination	[1]
111	ATFNTLFKGYGVAFS	ubiquitination	[1]
141	LRDFGMGKRGVEERI	ubiquitination	[1]
238	GPQQQIIKDSHKLED	ubiquitination	[1]
242	QIIKDSHKLEDFMIQ	acetylation	[2]
242	QIIKDSHKLEDFMIQ	ubiquitination	[1]
250	LEDFMIQKVKQNQST	ubiquitination	[1]
252	DFMIQKVKQNQSTLD	ubiquitination	[1]
276	SFLIHMQKEKYVNSE	ubiquitination	[1]
278	LIHMQKEKYVNSEFH	ubiquitination	[1]
324	KHPDVEAKVHEEIDR	ubiquitination	[1]
346	PQYEDHMKMPYTQAV	ubiquitination	[1]
374	GIPRRITKDTSFRGF	ubiquitination	[1]
385	FRGFFLPKGTEVFPI	ubiquitination	[1]
401	GSLMTDPKFFSSPKD	ubiquitination	[1]
407	PKFFSSPKDFNPQHF	ubiquitination	[1]
418	PQHFLDDKGQLKKIP	acetylation	[2]
418	PQHFLDDKGQLKKIP	ubiquitination	[1]
422	LDDKGQLKKIPAFLP	ubiquitination	[1]
423	DDKGQLKKIPAFLPF	ubiquitination	[1]
434	FLPFSTGKRFCLGDS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Highly active in the 7-alpha-hydroxylation of testosterone. 

Sequence Annotation

 METAL 437 437 Iron (heme axial ligand) (By similarity).
 MOD_RES 130 130 Phosphoserine.  

Keyword

 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008067; Cyt_P450_E_grp-I_CYP2A-like. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR01684; EP450ICYP2A.
 PR00385; P450.