UniProt Accession

 ABHD5_HUMAN; Q8WTS1; B2R9K0; Q9Y369 

Genbank Protein ID

 AL606838; AF151816; AK313811; AC105903; CH471055; BC021958 

Genbank Nucleotide ID

 CAD12731.1; AAD34053.1; BAG36547.1; EAW64699.1; AAH21958.1 

Protein Name

 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 

Protein Synonyms/Alias

 Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58 

Gene Name

 ABHD5 

Gene Synonyms/Alias

 NCIE2; CGI-58 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	PTSISHLKEAEEKML	ubiquitination	[1]
283	PMLQRIGKMHPDIPV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. 

Sequence Annotation

 MOTIF 327 332 HXXXXD motif.  

Keyword

 Acyltransferase; Cataract; Complete proteome; Cytoplasm; Deafness; Differentiation; Disease mutation; Fatty acid metabolism; Ichthyosis; Lipid biosynthesis; Lipid droplet; Lipid metabolism; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005811; C:lipid particle; ISS:UniProtKB.
 GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IEA:EC.
 GO:0042171; F:lysophosphatidic acid acyltransferase activity; IDA:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
 GO:0010891; P:negative regulation of sequestering of triglyceride; IDA:UniProtKB.
 GO:0006654; P:phosphatidic acid biosynthetic process; IDA:UniProtKB.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0010898; P:positive regulation of triglyceride catabolic process; IDA:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0019433; P:triglyceride catabolic process; TAS:Reactome. 

Interpro

 IPR000073; AB_hydrolase_1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR00111; ABHYDROLASE.