CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033118
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sphingomyelin phosphodiesterase 4 
Protein Synonyms/Alias
  
Gene Name
 SMPD4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99PMMKLVYKLQAEDYKubiquitination[1, 2]
106KLQAEDYKFDFPVSYubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 135 AA 
Protein Sequence
MAFPHLQQPS FLLASLKADS INKPFAQQCQ DLVKVIEDFP AKELHTIFPW LVESIFGSLD 60
GVLVGWNLRC LQGRVNPVEY SIVMEFLDPG GPMMKLVYKL QAEDYKFDFP VSYLPGPVKA 120
SIQECILPDS PLYHN 135 
Gene Ontology
 GO:0050290; F:sphingomyelin phosphodiesterase D activity; IEA:InterPro. 
Interpro
 IPR024129; Sphingomy_SMPD4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS