UniProt Accession

 G6PD1_MOUSE; Q00612 

Genbank Protein ID

 Z11911; AK088135; X53617; U88533; U88534 

Genbank Nucleotide ID

 CAA77967.1; BAC40166.1; CAA37679.1; AAB52998.1; AAB52999.1 

Protein Name

 Glucose-6-phosphate 1-dehydrogenase X 

Protein Synonyms/Alias

 G6PD 

Gene Name

 G6pdx 

Gene Synonyms/Alias

 G6pd; G6pd-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
497	TEADELMKRVGFQYE	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). 

Sequence Annotation

 NP_BIND 38 45 NADP 1 (By similarity).
 NP_BIND 401 403 NADP 2 (By similarity).
 NP_BIND 421 423 NADP 2 (By similarity).
 REGION 201 205 Substrate binding (By similarity).
 ACT_SITE 263 263 Proton acceptor (By similarity).
 BINDING 72 72 NADP 1 (By similarity).
 BINDING 147 147 NADP 1 (By similarity).
 BINDING 171 171 NADP 1; via carbonyl oxygen (By
 BINDING 171 171 Substrate (By similarity).
 BINDING 239 239 Substrate (By similarity).
 BINDING 258 258 Substrate (By similarity).
 BINDING 357 357 NADP 2 (By similarity).
 BINDING 360 360 Substrate (By similarity).
 BINDING 365 365 Substrate (By similarity).
 BINDING 366 366 NADP 2 (By similarity).
 BINDING 370 370 NADP 2 (By similarity).
 BINDING 393 393 NADP 2 (By similarity).
 BINDING 395 395 Substrate (By similarity).
 BINDING 487 487 NADP 2 (By similarity).
 BINDING 503 503 NADP 2 (By similarity).
 BINDING 509 509 NADP 2 (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 401 401 Phosphotyrosine.
 MOD_RES 503 503 Phosphotyrosine.
 MOD_RES 507 507 Phosphotyrosine.  

Keyword

 Acetylation; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glucose metabolism; NADP; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 515 AA 

Protein Sequence

Gene Ontology

 GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IDA:MGI.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0001998; P:angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure; IMP:MGI.
 GO:0048821; P:erythrocyte development; IMP:MGI.
 GO:0006749; P:glutathione metabolic process; IMP:MGI.
 GO:0032613; P:interleukin-10 production; IMP:MGI.
 GO:0032615; P:interleukin-12 production; IMP:MGI.
 GO:0006741; P:NADP biosynthetic process; IDA:MGI.
 GO:0019322; P:pentose biosynthetic process; IDA:MGI.
 GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
 GO:0006979; P:response to oxidative stress; IMP:MGI.
 GO:0002033; P:vasodilation by angiotensin involved in regulation of systemic arterial blood pressure; IMP:MGI. 

Interpro

 IPR001282; G6P_DH.
 IPR019796; G6P_DH_AS.
 IPR022675; G6P_DH_C.
 IPR022674; G6P_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02781; G6PD_C
 PF00479; G6PD_N 

SMART

  

PROSITE

 PS00069; G6P_DEHYDROGENASE 

PRINTS

 PR00079; G6PDHDRGNASE.