| Tag | Content |
|---|
| CPLM ID | CPLM-004124 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lysosome-associated membrane glycoprotein 2 |
Protein Synonyms/Alias | LAMP-2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; CD107b |
Gene Name | LAMP2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 402 | AYVIGRRKSYAGYQT | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. |
Sequence Annotation | REGION 29 192 First lumenal domain.
REGION 193 228 Hinge.
REGION 229 375 Second lumenal domain.
CARBOHYD 32 32 N-linked (GlcNAc...)
CARBOHYD 38 38 N-linked (GlcNAc...)
CARBOHYD 49 49 N-linked (GlcNAc...).
CARBOHYD 58 58 N-linked (GlcNAc...).
CARBOHYD 75 75 N-linked (GlcNAc...).
CARBOHYD 101 101 N-linked (GlcNAc...).
CARBOHYD 123 123 N-linked (GlcNAc...).
CARBOHYD 179 179 N-linked (GlcNAc...).
CARBOHYD 195 195 O-linked (GalNAc...).
CARBOHYD 196 196 O-linked (GalNAc...).
CARBOHYD 200 200 O-linked (GalNAc...).
CARBOHYD 203 203 O-linked (GalNAc...).
CARBOHYD 204 204 O-linked (GalNAc...).
CARBOHYD 207 207 O-linked (GalNAc...); partial.
CARBOHYD 209 209 O-linked (GalNAc...); partial.
CARBOHYD 210 210 O-linked (GalNAc...).
CARBOHYD 211 211 O-linked (GalNAc...).
CARBOHYD 213 213 O-linked (GalNAc...); partial.
CARBOHYD 229 229 N-linked (GlcNAc...).
CARBOHYD 242 242 N-linked (GlcNAc...).
CARBOHYD 257 257 N-linked (GlcNAc...).
CARBOHYD 275 275 N-linked (GlcNAc...).
CARBOHYD 300 300 N-linked (GlcNAc...).
CARBOHYD 307 307 N-linked (GlcNAc...)
CARBOHYD 317 317 N-linked (GlcNAc...).
CARBOHYD 356 356 N-linked (GlcNAc...).
DISULFID 41 79 By similarity.
DISULFID 153 189 By similarity.
DISULFID 232 265 By similarity.
DISULFID 331 368 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Endosome; Glycogen storage disease; Glycoprotein; Lysosome; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 410 AA |
Protein Sequence | MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF TVRYETTNKT 60
YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA NFTKAASTYS IDSVSFSYNT 120
GDNTTFPDAE DKGILTVDEL LAIRIPLNDL FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG 180
TVSTNEFLCD KDKTSTVAPT IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ 240
LNITQDKVAS VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 300
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL RVQPFNVTQG 360
KYSTAQECSL DDDTILIPII VGAGLSGLII VIVIAYVIGR RKSYAGYQTL 410 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031902; C:late endosome membrane; IDA:MGI. GO:0005765; C:lysosomal membrane; IDA:MGI. GO:0030670; C:phagocytic vesicle membrane; IEA:Compara. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0031088; C:platelet dense granule membrane; IDA:MGI. GO:0030168; P:platelet activation; TAS:Reactome. GO:0002576; P:platelet degranulation; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |