| Tag | Content |
|---|
| CPLM ID | CPLM-017947 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pumilio homolog 2 |
Protein Synonyms/Alias | Pumilio-2 |
Gene Name | PUM2 |
Gene Synonyms/Alias | KIAA0235; PUMH2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 818 | YGCRVIQKALESISS | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. |
Sequence Annotation | DOMAIN 706 1048 PUM-HD.
REPEAT 726 761 Pumilio 1.
REPEAT 762 797 Pumilio 2.
REPEAT 798 835 Pumilio 3.
REPEAT 836 871 Pumilio 4.
REPEAT 872 907 Pumilio 5.
REPEAT 908 943 Pumilio 6.
REPEAT 944 979 Pumilio 7.
REPEAT 983 1022 Pumilio 8.
REGION 1 260 Interaction with SNAPIN.
MOD_RES 82 82 Phosphoserine.
MOD_RES 136 136 Phosphoserine.
MOD_RES 178 178 Phosphoserine.
MOD_RES 182 182 Phosphoserine.
MOD_RES 184 184 Phosphothreonine.
MOD_RES 587 587 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1066 AA |
Protein Sequence | MNHDFQALAL ESRGMGELLP TKKFWEPDDS TKDGQKGIFL GDDEWRETAW GASHHSMSQP 60
IMVQRRSGQG FHGNSEVNAI LSPRSESGGL GVSMVEYVLS SSPADKLDSR FRKGNFGTRD 120
AETDGPEKGD QKGKASPFEE DQNRDLKQGD DDDSKINGRG LPNGMDADCK DFNRTPGSRQ 180
ASPTEVVERL GPNTNPSEGL GPLPNPTANK PLVEEFSNPE TQNLDAMEQV GLESLQFDYP 240
GNQVPMDSSG ATVGLFDYNS QQQLFQRTNA LTVQQLTAAQ QQQYALAAAQ QPHIAGVFSA 300
GLAPAAFVPN PYIISAAPPG TDPYTAAGLA AAATLAGPAV VPPQYYGVPW GVYPANLFQQ 360
QAAAAANNTA SQQAASQAQP GQQQVLRAGA GQRPLTPNQG QQGQQAESLA AAAAANPTLA 420
FGQGLATGMP GYQVLAPTAY YDQTGALVVG PGARTGLGAP VRLMAPTPVL ISSAAAQAAA 480
AAAAGGTASS LTGSTNGLFR PIGTQPPQQQ QQQPSTNLQS NSFYGSSSLT NSSQSSSLFS 540
HGPGQPGSTS LGFGSGNSLG AAIGSALSGF GSSVGSSASS SATRRESLST SSDLYKRSSS 600
SLAPIGQPFY NSLGFSSSPS PIGMPLPSQT PGHSLTPPPS LSSHGSSSSL HLGGLTNGSG 660
RYISAAPGAE AKYRSASSTS SLFSSSSQLF PPSRLRYNRS DIMPSGRSRL LEDFRNNRFP 720
NLQLRDLIGH IVEFSQDQHG SRFIQQKLER ATPAERQMVF NEILQAAYQL MTDVFGNYVI 780
QKFFEFGSLD QKLALATRIR GHVLPLALQM YGCRVIQKAL ESISSDQQSE MVKELDGHVL 840
KCVKDQNGNH VVQKCIECVQ PQSLQFIIDA FKGQVFVLST HPYGCRVIQR ILEHCTAEQT 900
LPILEELHQH TEQLVQDQYG NYVIQHVLEH GRPEDKSKIV SEIRGKVLAL SQHKFASNVV 960
EKCVTHASRA ERALLIDEVC CQNDGPHSAL YTMMKDQYAN YVVQKMIDMA EPAQRKIIMH 1020
KIRPHITTLR KYTYGKHILA KLEKYYLKNS PDLGPIGGPP NGML 1064 |
Gene Ontology | GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. GO:0034063; P:stress granule assembly; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |