CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031366
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Son of sevenless homolog 1 
Protein Synonyms/Alias
 cDNA FLJ53939, highly similar to Son of sevenless homolog 1 
Gene Name
 SOS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39DAQSAIEKRKRRNPLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
MLCQAQPRSA SDVEERVQKS FPHPIDKWAI ADAQSAIEKR KRRNPLSLPV EKIHPLLKEV 60
LGYKIDHQVS VYIVAVLEYI SADILKLVGN YVRNIRHYEI TKQDIKVAMC ADKVLMDMFH 120
QDVEDINILS LTDEEPSTSG EQTYYDLVKA FMAEIRQYIR ELNLIIKVFR EPFVSNSKLF 180
SANDVENIFS RIVDIHELSV KLLGHIEDTV EMTDEGSPHP LVGSCFEDLA EELAFDPYES 240
YARDILRPGF HDRFLSQLSK PGAALYLQSI GEGFKEAVQY VLPRLLLAPV YHCLHYFELL 300
KFPFGDLSRL RDSV 314 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR008937; Ras_GEF. 
Pfam
 PF00125; Histone
 PF00621; RhoGEF 
SMART
  
PROSITE
 PS50010; DH_2 
PRINTS