| Tag | Content |
|---|
| CPLM ID | CPLM-002829 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Complement C1s subcomponent |
Protein Synonyms/Alias | C1 esterase; Complement component 1 subcomponent s; Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain |
Gene Name | C1S |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 575 | SGWGRTEKRDRAVRL | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. |
Sequence Annotation | DOMAIN 16 130 CUB 1.
DOMAIN 131 172 EGF-like; calcium-binding.
DOMAIN 175 290 CUB 2.
DOMAIN 292 356 Sushi 1.
DOMAIN 357 423 Sushi 2.
DOMAIN 438 680 Peptidase S1.
ACT_SITE 475 475 Charge relay system.
ACT_SITE 529 529 Charge relay system.
ACT_SITE 632 632 Charge relay system.
METAL 60 60 Calcium.
METAL 68 68 Calcium.
METAL 113 113 Calcium.
METAL 131 131 Calcium.
METAL 132 132 Calcium; via carbonyl oxygen.
METAL 134 134 Calcium.
METAL 149 149 Calcium.
METAL 150 150 Calcium; via carbonyl oxygen.
METAL 153 153 Calcium; via carbonyl oxygen.
MOD_RES 149 149 (3R)-3-hydroxyasparagine.
CARBOHYD 174 174 N-linked (GlcNAc...).
CARBOHYD 406 406 N-linked (GlcNAc...).
DISULFID 65 83
DISULFID 135 147
DISULFID 143 156
DISULFID 158 171
DISULFID 175 202
DISULFID 234 251
DISULFID 294 341
DISULFID 321 354
DISULFID 359 403
DISULFID 386 421
DISULFID 425 549 Interchain (between heavy and light
DISULFID 595 618
DISULFID 628 659 |
Keyword | 3D-structure; Calcium; Complement pathway; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Hydroxylation; Immunity; Innate immunity; Metal-binding; Polymorphism; Protease; Reference proteome; Repeat; Serine protease; Signal; Sushi. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 688 AA |
Protein Sequence | MWCIVLFSLL AWVYAEPTMY GEILSPNYPQ AYPSEVEKSW DIEVPEGYGI HLYFTHLDIE 60
LSENCAYDSV QIISGDTEEG RLCGQRSSNN PHSPIVEEFQ VPYNKLQVIF KSDFSNEERF 120
TGFAAYYVAT DINECTDFVD VPCSHFCNNF IGGYFCSCPP EYFLHDDMKN CGVNCSGDVF 180
TALIGEIASP NYPKPYPENS RCEYQIRLEK GFQVVVTLRR EDFDVEAADS AGNCLDSLVF 240
VAGDRQFGPY CGHGFPGPLN IETKSNALDI IFQTDLTGQK KGWKLRYHGD PMPCPKEDTP 300
NSVWEPAKAK YVFRDVVQIT CLDGFEVVEG RVGATSFYST CQSNGKWSNS KLKCQPVDCG 360
IPESIENGKV EDPESTLFGS VIRYTCEEPY YYMENGGGGE YHCAGNGSWV NEVLGPELPK 420
CVPVCGVPRE PFEEKQRIIG GSDADIKNFP WQVFFDNPWA GGALINEYWV LTAAHVVEGN 480
REPTMYVGST SVQTSRLAKS KMLTPEHVFI HPGWKLLEVP EGRTNFDNDI ALVRLKDPVK 540
MGPTVSPICL PGTSSDYNLM DGDLGLISGW GRTEKRDRAV RLKAARLPVA PLRKCKEVKV 600
EKPTADAEAY VFTPNMICAG GEKGMDSCKG DSGGAFAVQD PNDKTKFYAA GLVSWGPQCG 660
TYGLYTRVKN YVDWIMKTMQ ENSTPRED 688 |
Gene Ontology | GO:0005576; C:extracellular region; TAS:Reactome. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB. GO:0006958; P:complement activation, classical pathway; TAS:Reactome. GO:0045087; P:innate immune response; TAS:Reactome. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |