CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039893
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protocadherin-1 
Protein Synonyms/Alias
  
Gene Name
 PCDH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
872QAGKKETKDLYAPKPubiquitination[1]
878TKDLYAPKPSGKASKubiquitination[1, 2]
898GKKSKSPKPVKPVEDubiquitination[1]
901SKSPKPVKPVEDEDEubiquitination[1, 2]
913EDEAGLQKSLKFNLMubiquitination[1, 2]
916AGLQKSLKFNLMSDAubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Cell adhesion; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1038 AA 
Protein Sequence
MEHLRHSPGP GGQRLLLPSM LLALLLLLAP SPGHATRVVY KVPEEQPPNT LIGSLAADYG 60
FPDVGHLYKL EVGAPYLRVD GKTGDIFTTE TSIDREGLRE CQNQLPGDPC ILEFEVSITD 120
LVQNGSPRLL EGQIEVQDIN DNTPNFASPV ITLAIPENTN IGSLFPIPLA SDRDAGPNGV 180
ASYELQAGPE AQELFGLQVA EDQEEKQPQL IVMGNLDRER WDSYDLTIKV QDGGSPPRAS 240
SALLRVTVLD TNDNAPKFER PSYEAELSEN SPIGHSVIQV KANDSDQGAN AEIEYTFHQA 300
PEVVRRLLRL DRNTGLITVQ GPVDREDLST LRFSVLAKDR GTNPKSARAQ VVVTVKDMND 360
NAPTIEIRGI GLVTHQDGMA NISEDVAEET AVALVQVSDR DEGENAAVTC VVAGDVPFQL 420
RQASETGSDS KKKYFLQTTT PLDYEKVKDY TIEIVAVDSG NPPLSSTNSL KVQVVDVNDN 480
APVFTQSVTE VAFPENNKPG EVIAEITASD ADSGSNAELV YSLEPEPAAK GLFTISPETG 540
EIQVKTSLDR EQRESYELKV VAADRGSPSL QGTATVLVNV LDCNDNDPKF MLSGYNFSVM 600
ENMPALSPVG MVTVIDGDKG ENAQVQLSVE QDNGDFVIQN GTGTILSSLS FDREQQSTYT 660
FQLKAVDGGV PPRSAYVGVT INVLDENDNA PYITAPSNTS HKLLTPQTRL GETVSQVAAE 720
DFDSGVNAEL IYSIAGGNPY GLFQIGSHSG AITLEKEIER RHHGLHRLVV KVSDRGKPPR 780
YGTALVHLYV NETLANRTLL ETLLGHSLDT PLDIDIAGDP EYERSKQRGN ILFGVVAGVV 840
AVALLIALAV LVRYCRQREA KSGYQAGKKE TKDLYAPKPS GKASKGNKSK GKKSKSPKPV 900
KPVEDEDEAG LQKSLKFNLM SDAPGDSPRI HLPLNYPPGS PDLGRHYRSN SPLPSIQLQP 960
QSPSASKKHQ VVQDLPPANT FVGTGDTTST GSEQYSDYSY RTNPPKYPSK QVGQPFQLST 1020
PQPLPHPYHG AIWTEVWE 1038 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR013164; Cadherin_N.
 IPR013585; Protocadherin. 
Pfam
 PF00028; Cadherin
 PF08266; Cadherin_2
 PF08374; Protocadherin 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.