CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036941
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Solute carrier family 43 member 3 
Protein Synonyms/Alias
  
Gene Name
 SLC43A3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
77LFSTPDCKAQDERFSubiquitination[1]
190SAVFLIIKLLYEKGIubiquitination[2]
195IIKLLYEKGISLRASubiquitination[1]
246CPGNGTTKEEKETAEubiquitination[1, 3]
249NGTTKEEKETAEHENubiquitination[1, 3]
262ENRELQSKEFLSAKEubiquitination[1, 2, 3, 4, 5, 6]
268SKEFLSAKEETPGAGacetylation[7]
268SKEFLSAKEETPGAGubiquitination[1, 2, 3, 4, 5, 6]
277ETPGAGQKQELRSFWubiquitination[1, 2, 3, 4, 5, 6]
497YRECRTWKESPSAIAubiquitination[1, 2, 3, 6, 8]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [8] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MAGQGLPLHV ATLLTGLLEC LGFAGVLFGW PSLVFVFKNE DYFKDLCGPD AGPIGNATGQ 60
AGRLGCMGDL FSTPDCKAQD ERFSLIFTLG SFMNNFMTFP TGYIFDRFKT TVARLIAIFF 120
YTTATLIIAF TSAGSAVLLF LAMPMLTIGG ILFLITNLQI GNLFGQHRST IITLYNGAFD 180
SSSAVFLIIK LLYEKGISLR ASFIFISVCS TWHVARTFLL MPRGHIPYPL PPNYSYGLCP 240
GNGTTKEEKE TAEHENRELQ SKEFLSAKEE TPGAGQKQEL RSFWSYAFSR RFAWHLVWLS 300
VIQLWHYLFI GTLNSLLTNM AGGDMARVST YTNAFAFTQF GVLCAPWNGL LMDRLKQKYQ 360
KEARKTGSST LAVALCSTVP SLALTSLLCL GFALCASVPI LPLQYLTFIL QVISRSFLYG 420
SNAAFLTLAF PSEHFGKLFG LVMALSAVVS LLQFPIFTLI KGSLQNDPFY VNVMFMLAIL 480
LTFFHPFLVY RECRTWKESP SAIA 504 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 
Interpro
 IPR011701; MFS.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR027192; SLC43.
 IPR027197; SLC43A3. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
  
PRINTS