CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004447
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2',3'-cyclic-nucleotide 3'-phosphodiesterase 
Protein Synonyms/Alias
 CNP; CNPase 
Gene Name
 Cnp 
Gene Synonyms/Alias
 Cnp1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MSSSGAKEKPELQFubiquitination[1]
9SSSGAKEKPELQFPFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. 
Sequence Annotation
 ACT_SITE 250 250 Proton acceptor.
 ACT_SITE 329 329 Proton donor.
 BINDING 252 252 Substrate.
 BINDING 331 331 Substrate.
 MOD_RES 110 110 Phosphotyrosine.
 MOD_RES 372 372 Phosphotyrosine.
 MOD_RES 417 417 Cysteine methyl ester (Probable).
 LIPID 417 417 S-farnesyl cysteine (Probable).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Lipoprotein; Membrane; Methylation; Phosphoprotein; Prenylation; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 420 AA 
Protein Sequence
MSSSGAKEKP ELQFPFLQDE DTVATLHECK TLFILRGLPG SGKSTLARLI LEKYHDGTKM 60
VSADAYKIIP GSRADFSEAY KRLDEDLAGY CRRDIRVLVL DDTNHERERL DQLFEMADQY 120
QYQVVLVEPK TAWRLDCAQL KEKNQWQLSA DDLKKLKPGL EKDFLPLYFG WFLTKKSSET 180
LRKAGQVFLE ELGNHKAFKK ELRHFISGDE PKEKLELVSY FGKRPPGVLH CTTKFCDYGK 240
AAGAEEYAQQ EVVKRSYGKA FKLSISALFV TPKTAGAQVV LTDQELQLWP SDLDKPSASE 300
GLPPGSRAHV TLGCAADVQP VQTGLDLLDI LQQVKGGSQG EAVGELPRGK LYSLGKGRWM 360
LSLTKKMEVK AIFTGYYGKG KPVPIHGSRK GGAMQICTII 400 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0035749; C:myelin sheath adaxonal region; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0031143; C:pseudopodium; IEA:Compara.
 GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IDA:MGI.
 GO:0030551; F:cyclic nucleotide binding; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0009214; P:cyclic nucleotide catabolic process; IEA:InterPro.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0009636; P:response to toxic substance; IDA:MGI.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR008431; CNPase.
 IPR027417; P-loop_NTPase.
 IPR009097; RNA_ligase/cNuc_Pdiesterase. 
Pfam
 PF05881; CNPase 
SMART
  
PROSITE
  
PRINTS