CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017182
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable lysosomal cobalamin transporter 
Protein Synonyms/Alias
 LMBR1 domain-containing protein 1; Protein N90b 
Gene Name
 Lmbrd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
267ARDRRALKQCEERLRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity). 
Sequence Annotation
 MOD_RES 235 235 Phosphothreonine.
 MOD_RES 525 525 Phosphoserine (By similarity).
 MOD_RES 528 528 Phosphoserine (By similarity).
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 85 85 N-linked (GlcNAc...) (Potential).
 CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
 CARBOHYD 167 167 N-linked (GlcNAc...) (Potential).
 CARBOHYD 344 344 N-linked (GlcNAc...) (Potential).
 CARBOHYD 445 445 N-linked (GlcNAc...) (Potential).
 CARBOHYD 454 454 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cobalamin; Cobalt; Complete proteome; Glycoprotein; Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 537 AA 
Protein Sequence
MAAAAAELVI GWCIFGLLLL AILAFCWVYV RKYQSQRESE VVSTVTAIFS LAVALITSAL 60
LPVDIFLVSY MKNQNGTFKD WADANVTVQI ENTVLYGYYT LYSVILFCVF FWIPFVYFYY 120
EEKDEDDASK CTQIKTALKY TLGFVVICAL LLLVGAFVPL HLPNNNNSTE WEKVKLLFED 180
LGTGQGLAAL SFSISSLTLI GMLAAITYTA YGMSALPLNL IKGTRSTAYE RLENTEDIEE 240
VEQHIQTIRS KSKDGRPLPA RDRRALKQCE ERLRTLRKRE RHLEFIENSW WTKFCGALRP 300
LKIIWGIFFI LVALLFVISL FLSNLDKALH SAGIDSGFII FGTNLSNPLN MLLPLLQTVF 360
PLDYILITII IMYFIFTSMA GIRNIGIWFF WIRLYKIRRG RTRPQALLFL CMILLLIVLH 420
TSYMIYSLAP QYVMYGSQNY LIESNITSDA HKGNSTLAVP KRCDADAPKD QCTVTRTYIF 480
LHKFWFFSAA YYFGNWAFLV VFLIGLIVSC CKGKKSVIEG VDEDSDLSDD EPSAYSA 537 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR006876; LMBR1-like_membr_prot. 
Pfam
 PF04791; LMBR1 
SMART
  
PROSITE
  
PRINTS