CPLM-023944

Genbank Nucleotide ID

Feline leukemia virus subgroup C receptor-related protein 1

Protein Synonyms/Alias

Feline leukemia virus subgroup C receptor; hFLVCR

Homo sapiens (Human)

Position	Peptide	Type	References
33	PRGAPVGKESVELQN	ubiquitination	[1, 2]
322	PPEEYSYKKSIRNLF	ubiquitination	[1, 2, 3]
323	PEEYSYKKSIRNLFK	ubiquitination	[1]
530	GITNVDVKAIPADSP	ubiquitination	[1, 2, 4, 5]
549	PKTVMLSKQSESAI*	ubiquitination	[1, 2, 4, 6, 7]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[3] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
[6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro.

MOD_RES 56 56 Phosphoserine.

Cell membrane; Complete proteome; Disease mutation; Membrane; Neurodegeneration; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Retinitis pigmentosa; Transmembrane; Transmembrane helix; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0015232; F:heme transporter activity; IDA:UniProtKB.
GO:0008219; P:cell death; IEA:UniProtKB-KW.
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
GO:0030218; P:erythrocyte differentiation; IEA:Compara.
GO:0060323; P:head morphogenesis; IEA:Compara.
GO:0097037; P:heme export; IMP:UniProtKB.
GO:0001701; P:in utero embryonic development; IEA:Compara.
GO:0035264; P:multicellular organism growth; IEA:Compara.
GO:0007275; P:multicellular organismal development; TAS:ProtInc.
GO:0046620; P:regulation of organ growth; IEA:Compara.
GO:0048536; P:spleen development; IEA:Compara.
GO:0055085; P:transmembrane transport; TAS:Reactome.

IPR011701; MFS.
IPR020846; MFS_dom.
IPR016196; MFS_dom_general_subst_transpt.