CPLM-021958

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021958

UniProt Accession

MYNN_HUMAN; Q9NPC7; B2R6C9; Q6QHA6; Q6QHA7; Q6R3G1; Q6R3G2; Q6R4A0; Q7Z716; Q7Z717; Q86Z11; Q86Z12; Q9NS01; Q9UIW8

Genbank Protein ID

AF148848; AY286322; AY286321; AY286328; AY286323; AY286325; AY286324; AY286326; AY286327; AY514901; AY515294; AY515691; AY515692; AY541760; AY541761; AB079777; AB079778; AB079779; AF076249; AF155508; AK021646; AK092022; AK312527; AL133070; BX648128; CH471052; CH471052; BC033620

Genbank Nucleotide ID

AAF73138.1; AAP44763.1; AAP44763.1; AAP44764.1; AAP44764.1; AAP44764.1; AAP44764.1; AAP44764.1; AAP44764.1; AAR99055.1; AAR99843.1; AAS38566.1; AAS38567.1; AAS87376.1; AAS87377.1; BAC55898.1; BAC55899.1; BAC55900.1; AAF80160.1; AAF74822.1; BAB13862.1; BAG52468.1; BAG35426.1; CAB61393.1; CAI46035.1; EAW78544.1; EAW78546.1; AAH33620.1

Protein Name

Myoneurin

Protein Synonyms/Alias

Zinc finger and BTB domain-containing protein 31

Gene Name

MYNN

Gene Synonyms/Alias

OSZF; ZBTB31; SBBIZ1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
69	FLDQSQVKADGFQKL	ubiquitination	[1]
155	RDYNNREKSEVSTDL	ubiquitination	[2]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Sequence Annotation

DOMAIN 24 89 BTB.
ZN_FING 302 324 C2H2-type 1.
ZN_FING 330 352 C2H2-type 2.
ZN_FING 358 381 C2H2-type 3.
ZN_FING 387 409 C2H2-type 4.
ZN_FING 415 437 C2H2-type 5.
ZN_FING 443 465 C2H2-type 6.
ZN_FING 471 493 C2H2-type 7.
ZN_FING 499 522 C2H2-type 8.
MOTIF 174 190 Nuclear localization signal (Potential).
MOTIF 257 262 Nuclear localization signal (Potential).
MOD_RES 289 289 Phosphoserine.

Keyword

3D-structure; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

610 AA

Protein Sequence

MQYSHHCEHL LERLNKQREA GFLCDCTIVI GEFQFKAHRN VLASFSEYFG AIYRSTSENN 60
VFLDQSQVKA DGFQKLLEFI YTGTLNLDSW NVKEIHQAAD YLKVEEVVTK CKIKMEDFAF 120
IANPSSTEIS SITGNIELNQ QTCLLTLRDY NNREKSEVST DLIQANPKQG ALAKKSSQTK 180
KKKKAFNSPK TGQNKTVQYP SDILENASVE LFLDANKLPT PVVEQVAQIN DNSELELTSV 240
VENTFPAQDI VHTVTVKRKR GKSQPNCALK EHSMSNIASV KSPYEAENSG EELDQRYSKA 300
KPMCNTCGKV FSEASSLRRH MRIHKGVKPY VCHLCGKAFT QCNQLKTHVR THTGEKPYKC 360
ELCDKGFAQK CQLVFHSRMH HGEEKPYKCD VCNLQFATSS NLKIHARKHS GEKPYVCDRC 420
GQRFAQASTL TYHVRRHTGE KPYVCDTCGK AFAVSSSLIT HSRKHTGEKP YICGICGKSF 480
ISSGELNKHF RSHTGERPFI CELCGNSYTD IKNLKKHKTK VHSGADKTLD SSAEDHTLSE 540
QDSIQKSPLS ETMDVKPSDM TLPLALPLGT EDHHMLLPVT DTQSPTSDTL LRSTVNGYSE 600
PQLIFLQQLY 610

Gene Ontology

GO:0005634; C:nucleus; IDA:HPA.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0006351; P:transcription, DNA-dependent; TAS:ProtInc.

Interpro

IPR000210; BTB/POZ-like.
IPR011333; BTB/POZ_fold.
IPR013069; BTB_POZ.
IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.

Pfam

PF00651; BTB

SMART

SM00225; BTB
SM00355; ZnF_C2H2

PROSITE

PS50097; BTB
PS00028; ZINC_FINGER_C2H2_1
PS50157; ZINC_FINGER_C2H2_2

PRINTS