| Tag | Content |
|---|
| CPLM ID | CPLM-014789 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone H2A deubiquitinase MYSM1 |
Protein Synonyms/Alias | 2A-DUB; Myb-like, SWIRM and MPN domain-containing protein 1 |
Gene Name | Mysm1 |
Gene Synonyms/Alias | Kiaa1915 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 76 | EEYYLSNKSLPGKFW | ubiquitination | [1] | | 666 | RDIDTQAKYQSYFSR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). |
Sequence Annotation | DOMAIN 113 164 SANT.
DOMAIN 363 461 SWIRM.
DOMAIN 563 673 MPN.
MOTIF 647 660 JAMM motif.
MOTIF 765 769 LXXLL motif.
METAL 647 647 Zinc; catalytic (By similarity).
METAL 649 649 Zinc; catalytic (By similarity).
METAL 660 660 Zinc; catalytic (By similarity).
MOD_RES 215 215 Phosphoserine (By similarity).
MOD_RES 233 233 Phosphothreonine (By similarity).
MOD_RES 332 332 Phosphoserine (By similarity). |
Keyword | Activator; Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Phosphoprotein; Protease; Reference proteome; Transcription; Transcription regulation; Ubl conjugation pathway; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 819 AA |
Protein Sequence | MEAEEADVDV EGDVAAAAQP GNDESTASVF QDHYLDSTWR RENGCLPWTL DSTISDENRA 60
IIEKMLLEEE YYLSNKSLPG KFWVNQKEDN KKYTNSLQKS SKAMVDSPAK PASHSVKWTV 120
EEKELFEQGL AKFGRRWTKI ATLLKSRTVL QVKSYARQYF KNKVKWDVEK ETPTQKSSSD 180
LQVKNKDDRT KAWAAACLRG SADPCLNAVK IEKLSDDEDV DITDELDELT SQTSQNSGSH 240
LTLDVPNSKM YTTNQGELCQ EGPLAKSSGE SLQNVKQGEG EACSSSEIAS WAEKQKSTDK 300
NSAELNEKYN KVVEEHTLHR GEVREEAKHS PSPEPCERQD SSGNEMLLPP CQIEEENHEG 360
EELKPPEQEV EIDRNVIQEE EKQAIPEFFE GRQTKTPERY LKIRNYILDQ WEICKPKYLN 420
KTSVRPGLKN CGDVNCIGRI HTYLELIGAI NFGCEQAVYN RPQPLDKVRA ADRKDAEAAY 480
QLAWRLQSMR TRRRRVRDPW GNWCDAKDLE GQTFEHLSVE EMARRKEEEK CKPIKFSKAS 540
KLPKSSLDPF QLIPCNFFSE EKQEPFQVKV AAEALLIMNL HAHVSMAEVI GLLGGRYSEA 600
DKVLEVCAAE PCNSLSTGLQ CEMDPVSQTQ ASETLALRGY SVIGWYHSHP AFDPNPSLRD 660
IDTQAKYQSY FSRGGAKFIG MIVSPYNRSN PLPYSQITCL VISEEVSPDG TYRLPYKFEV 720
QQMLEEPQWE LVFEKTRWII EKYRLSNSSV PMDRIFRRDS DLTCLQKLLE CLRKTLSKVA 780
NCFIAEEFLT QIENLFLSNY KSKEENGLAE EDSTKELFM 819 |
Gene Ontology | GO:0005634; C:nucleus; ISS:UniProtKB. GO:0003682; F:chromatin binding; IEA:InterPro. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0042393; F:histone binding; ISS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008237; F:metallopeptidase activity; ISS:UniProtKB. GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB. GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB. GO:0016578; P:histone deubiquitination; ISS:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |