UniProt Accession

 F10A1_RAT; P50503 

Genbank Protein ID

 X82021; BC078804 

Genbank Nucleotide ID

 CAA57546.1; AAH78804.1 

Protein Name

 Hsc70-interacting protein 

Protein Synonyms/Alias

 Hip; Protein FAM10A1; Protein ST13 homolog 

Gene Name

 St13 

Gene Synonyms/Alias

 Fam10a1; Hip 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
152	RLAILYAKRASVFVK	acetylation	[1]
185	PDSAQPYKWRGKAHR	acetylation	[1]
359	KVMNLISKLSAKFGG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. 

Sequence Annotation

 REPEAT 113 146 TPR 1.
 REPEAT 147 180 TPR 2.
 REPEAT 181 214 TPR 3.
 DOMAIN 318 357 STI1.
 MOD_RES 345 345 Phosphoserine; by GRK5 (By similarity).  

Keyword

 Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 368 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0032564; F:dATP binding; IDA:RGD.
 GO:0030544; F:Hsp70 protein binding; IDA:RGD.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0019904; F:protein domain specific binding; IDA:RGD.
 GO:0051082; F:unfolded protein binding; IDA:RGD.
 GO:0070389; P:chaperone cofactor-dependent protein refolding; IDA:RGD.
 GO:0061084; P:negative regulation of protein refolding; IDA:RGD.
 GO:0051260; P:protein homooligomerization; IDA:RGD. 

Interpro

 IPR006636; STI1_HS-bd.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1
 PF07719; TPR_2 

SMART

 SM00727; STI1
 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS