CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Roundabout homolog 1 
Protein Synonyms/Alias
 Roundabout homolog 1 (Drosophila) 
Gene Name
 Robo1 
Gene Synonyms/Alias
 mCG_142127 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
898STYAGIRKVPSFTFTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1612 AA 
Protein Sequence
MIAEPARFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 60
EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYICVA RNYLGEAVSH 120
NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 180
IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 240
EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 300
EASATLTVQE PPHFVVKPRD QVVALGRTVT FQCEATGNPQ PAIFWRREGS QNLLFSYQPP 360
QSSSRFSVSQ TGDLTITNVQ RSDVGYYICQ TLNVAGSIIT KAYLEVTDVI ADRPPPVIRQ 420
GPVNQTVAVD GTLILSCVAT GSPAPTILWR KDGVLVSTQD SRIKQLESGV LQIRYAKLGD 480
TGRYTCTAST PSGEATWSAY IEVQEFGVPV QPPRPTDPNL IPSAPSKPEV TDVSKNTVTL 540
SWQPNLNSGA TPTSYIIEAF SHASGSSWQT AAENVKTETF AIKGLKPNAI YLFLVRAANA 600
YGISDPSQIS DPVKTQDVPP TSQGVDHKQV QRELGNVVLH LHNPTILSSS SVEVHWTVDQ 660
QSQYIQGYKI LYRPSGASHG ESEWLVFEVR TPTKNSVVIP DLRKGVNYEI KARPFFNEFQ 720
GADSEIKFAK TLEEAPSAPP RSVTVSKNDG NGTAILVTWQ PPPEDTQNGM VQEYKVWCLG 780
NETKYHINKT VDGSTFSVVI PSLVPGIRYS VEVAASTGAG PGVKSEPQFI QLDSHGNPVS 840
PEDQVSLAQQ ISDVVRQPAF IAGIGAACWI ILMVFSIWLY RHRKKRNGLT STYAGIRKVP 900
SFTFTPTVTY QRGGEAVSSG GRPGLLNISE PATQPWLADT WPNTGNNHND CSINCCTAGN 960
GNSDSNLTTY SRPADCIANY NNQLDNKQTN LMLPESTVYG DVDLSNKINE MKTFNSPNLK 1020
DGRFVNPSGQ PTPYATTQLI QANLSNNMNN GAGDSSEKHW KPPGQQKPEV APIQYNIMEQ 1080
NKLNKDYRAN DTIPPTIPYN QSYDQNTGGS YNSSDRGSST SGSQGHKKGA RTPKAPKQGG 1140
MNWADLLPPP PAHPPPHSNS EEYNMSVDES YDQEMPCPVP PARMYLQQDE LEEEEDERGP 1200
TPPVRGAASS PAAVSYSHQS TATLTPSPQE ELQPMLQDCP EDLGHMPHPP DRRRQPVSPP 1260
PPPRPISPPH TYGYISGPLV SDMDTDAPEE EEDEADMEVA KMQTRRLLLR GLEQTPASSV 1320
GDLESSVTGS MINGWGSASE EDNISSGRSS VSSSDGSFFT DADFAQAVAA AAEYAGLKVA 1380
RRQMQDAAGR RHFHASQCPR PTSPVSTDSN MSAVVIQKAR PAKKQKHQPG HLRREAYADD 1440
LPPPPVPPPA IKSPTVQSKA QLEVRPVMVP KLASIEARTD RSSDRKGGSY KGREALDGRQ 1500
VTDLRTNPSD PREAQEQPND GKGRGTKAAK RDLPPAKTHL GQEDILPYCR PTFPTSNNPR 1560
DPSSSSSMSS RGSGSRQREQ ANVGRRNMAE MQVLGGFERG DENNEELEET ES 1612 
Gene Ontology
 GO:0030673; C:axolemma; IDA:MGI.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Compara.
 GO:0021836; P:chemorepulsion involved in postnatal olfactory bulb interneuron migration; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; IEA:Compara.
 GO:0060763; P:mammary duct terminal end bud growth; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IEA:Compara.
 GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0050925; P:negative regulation of negative chemotaxis; IEA:Compara.
 GO:0050772; P:positive regulation of axonogenesis; IEA:Compara.
 GO:0035385; P:Roundabout signaling pathway; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR003596; Ig_V-set_subgr. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00408; IGc2
 SM00406; IGv 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS