UniProt Accession

 DHSB_SALTY; Q8ZQU2 

Genbank Protein ID

 AE006468 

Genbank Nucleotide ID

 AAL19679.1 

Protein Name

 Succinate dehydrogenase iron-sulfur subunit 

Protein Synonyms/Alias

  

Gene Name

 sdhB 

Gene Synonyms/Alias

 STM0735 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
70	DGLNMNGKNGLACIT	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth (By similarity). 

Sequence Annotation

 DOMAIN 1 97 2Fe-2S ferredoxin-type.
 DOMAIN 139 169 4Fe-4S ferredoxin-type.
 METAL 55 55 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 60 60 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 75 75 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 149 149 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 152 152 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 155 155 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 159 159 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 206 206 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 212 212 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 216 216 Iron-sulfur 2 (4Fe-4S) (By similarity).
 BINDING 164 164 Ubiquinone; shared with SdhD subunit (By  

Keyword

 2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Reference proteome; Transport; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000104; F:succinate dehydrogenase activity; IEA:EC.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001041; 2Fe-2S_ferredoxin-type.
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR017900; 4Fe4S_Fe_S_CS.
 IPR012675; Beta-grasp_dom.
 IPR012285; Fum_reductase_C.
 IPR009051; Helical_ferredxn.
 IPR004489; Succ_DH/fum_Rdtase_Fe-S.
 IPR025192; Succ_DH/fum_Rdtase_N. 

Pfam

 PF13085; Fer2_3 

SMART

  

PROSITE

 PS00197; 2FE2S_FER_1
 PS51085; 2FE2S_FER_2
 PS00198; 4FE4S_FER_1
 PS51379; 4FE4S_FER_2 

PRINTS