CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014456
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Casein kinase I isoform gamma-1 
Protein Synonyms/Alias
 CKI-gamma 1 
Gene Name
 Csnk1g1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
255SLPWQGLKADTLKERubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN (By similarity). 
Sequence Annotation
 DOMAIN 44 315 Protein kinase.
 NP_BIND 50 58 ATP (By similarity).
 ACT_SITE 164 164 Proton acceptor (By similarity).
 BINDING 73 73 ATP (By similarity).
 MOD_RES 344 344 Phosphoserine (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI GCGNFGELRL 60
GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG LPQVYYFGPC GKYNAMVLEL 120
LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS RMEYVHSKNL IYRDVKPENF LIGRQGNKKE 180
HVIHIIDFGL AKEYIDPETK KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM 240
FMYFLRGSLP WQGLKADTLK ERYQKIGDTK RSTPIEALCE NFPEEMMTYL RYVRRLDFFE 300
KPDYEYLRNL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT RESHTHRDRP 360
SQQQPLRNQP RSLTAEWFVL APLSHPPAPT 390 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0001948; F:glycoprotein binding; IDA:RGD.
 GO:0000287; F:magnesium ion binding; IDA:RGD.
 GO:0042277; F:peptide binding; IDA:RGD.
 GO:0051219; F:phosphoprotein binding; IDA:RGD.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:RGD.
 GO:0046777; P:protein autophosphorylation; IDA:RGD.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR022247; Casein_kinase-1_gamma_C.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF12605; CK1gamma_C
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS