Tag | Content |
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CPLM ID | CPLM-003482 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NAD(P)H-flavin reductase |
Protein Synonyms/Alias | Aquacobalamin reductase; FMN reductase; Ferrisiderophore reductase C; NAD(P)H:flavin oxidoreductase; Riboflavin reductase [NAD(P)H] |
Gene Name | fre |
Gene Synonyms/Alias | fadI; flrD; fsrC; ubiB; b3844; JW3820 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
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46 | VVMDERDKRPFSMAS | acetylation | [1] | 208 | AGRFEMAKIARDLFC | acetylation | [1] |
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Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduce the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator. |
Sequence Annotation | DOMAIN 2 99 FAD-binding FR-type. NP_BIND 111 115 Pyridine (By similarity). |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; FMN; Ion transport; Iron; Iron transport; NAD; NADP; Oxidoreductase; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 233 AA |
Protein Sequence | MTTLSCKVTS VEAITDTVYR VRIVPDAAFS FRAGQYLMVV MDERDKRPFS MASTPDEKGF 60 IELHIGASEI NLYAKAVMDR ILKDHQIVVD IPHGEAWLRD DEERPMILIA GGTGFSYARS 120 ILLTALARNP NRDITIYWGG REEQHLYDLC ELEALSLKHP GLQVVPVVEQ PEAGWRGRTG 180 TVLTAVLQDH GTLAEHDIYI AGRFEMAKIA RDLFCSERNA REDRLFGDAF AFI 233 |
Gene Ontology | GO:0047138; F:aquacobalamin reductase activity; IEA:EC. GO:0052875; F:riboflavin reductase (NADH) activity; IEA:EC. GO:0042602; F:riboflavin reductase (NADPH) activity; IEA:EC. GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. |
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