| Tag | Content |
|---|
| CPLM ID | CPLM-023329 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 26S proteasome non-ATPase regulatory subunit 1 |
Protein Synonyms/Alias | 26S proteasome regulatory complex subunit p110; 26S proteasome regulatory subunit RPN2 |
Gene Name | Rpn2 |
Gene Synonyms/Alias | CG11888 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 318 | EETPADDKVERTIDS | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. |
Sequence Annotation | REPEAT 418 452 PC 1.
REPEAT 456 489 PC 2.
REPEAT 491 525 PC 3.
REPEAT 526 560 PC 4.
REPEAT 562 595 PC 5.
REPEAT 596 631 PC 6.
REPEAT 632 664 PC 7.
REPEAT 666 701 PC 8.
REPEAT 702 742 PC 9.
REPEAT 745 777 PC 10.
MOD_RES 291 291 Phosphothreonine.
MOD_RES 298 298 Phosphoserine.
MOD_RES 303 303 Phosphoserine.
MOD_RES 305 305 Phosphoserine.
MOD_RES 310 310 Phosphothreonine. |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Proteasome; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1020 AA |
Protein Sequence | MSLTSAAGII SLLDEPMPDL KVFALKKLDN IVDEFWPEIS ESIEKIEMLH EDRSFPENKL 60
AGMVASKVFY HLGSFEDALT YALGAGDLFD VNARNEYTET IIAKCIDFYI AQRVEFIENP 120
KEASVVDERL EGIVNRMIQR CLDDNQFRQA LGIALETRRM DTFKDAIMKS DDVRGMLAYA 180
YNVTMSLIQN RGFRNEVLRC LVSLYRDLGV PDYVNMCQCL IFLEDPFAVA EMLDNLTRSS 240
VETNNLMAYQ IAFDLYESAT QEFLGNVLQH LKNTAPIPTA LPSTFKPQGT TSEDGAKSEG 300
DKSKSDEDIT EETPADDKVE RTIDSLNEVE KLHQKNIEKL ISILSGEVSI DLQLQFLIRS 360
NHADLQVLRG TKEAVRVSIC HTATVIANAF MHSGTTSDQF LRDNLDWLAR ATNWAKLTAT 420
ASLGVIHRGH EKDSLALMQS YLPKEAGPSS GYSEGGALYA LGLIHANHGA NIIDYLLQQL 480
KDAQNENVRH GGCLGLGLAG MGTHRQDLYE QLKFNLYQDD AVTGEAAGIA MGMVMLGSKN 540
AQAIEDMVSY AQETQHEKIL RGLAVGISLT MFSRLEEADP LVTSLSSDKD PVLRRSGMYT 600
IAMAYNGTGS NKAIRKLLHV AVSDVNDDVR RAAVTAIGFI LFRSPEQCPS VVSLLAESYN 660
PHVRYGAAMA LGIACAGTGL REAIALLEPM VKFDPVNFVR QGALIASAMI LIQHTDQSCP 720
KSTFFRQLYA EVISNKHEDV MAKYGAILAQ GIIDAGGRNA TLSLQSRTGH TNLQAVVGML 780
AFTQYWYWFP LAHTLSLAFT PTCVIGLNSD LKMPKMEYKS AAKPSLYAYP APLEEKKSEE 840
REKVATAVLS IAARQKRREN ADKKEDEKMD VDEDSKEGAA VKKDEEAKAD EKMVTDEKPK 900
KKDEKEKKKE EDKEKEAAGT SSEKDKDKEK DKKEKKEPEP TSEILQNPAR VLRQQLKVLS 960
VIDGQSYEPL KDVTIGGIIV FQHTGKAEDQ ELVEPVAAFG PMNDEEKEPE PPEPFEYIED 1020 |
Gene Ontology | GO:0008540; C:proteasome regulatory particle, base subcomplex; ISS:FlyBase. GO:0030234; F:enzyme regulator activity; IEA:InterPro. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:FlyBase. GO:0050790; P:regulation of catalytic activity; IEA:GOC. GO:0042176; P:regulation of protein catabolic process; IEA:InterPro. GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |