UniProt Accession

 COPZ1_MOUSE; P61924; Q9Y3C3 

Genbank Protein ID

 AB037370; AK003302; BC002246; BC058524; BC085314 

Genbank Nucleotide ID

 BAA90303.1; BAB22703.1; AAH58524.1; AAH85314.1 

Protein Name

 Coatomer subunit zeta-1 

Protein Synonyms/Alias

 Zeta-1-coat protein; Zeta-1 COP 

Gene Name

 Copz1 

Gene Synonyms/Alias

 Copz 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	DGDRLFAKYYDDTYP	acetylation	[1]
39	DDTYPSVKEQKAFEK	ubiquitination	[2]
46	KEQKAFEKNIFNKTH	ubiquitination	[2]
51	FEKNIFNKTHRTDSE	ubiquitination	[2]
168	SQVLQSAKEQIKWSL	ubiquitination	[2]
172	QSAKEQIKWSLLR**	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0030126; C:COPI vesicle coat; ISS:UniProtKB.
 GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 

Interpro

 IPR022775; AP_mu_sigma_su.
 IPR000804; Clathrin_sm-chain_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00989; CLAT_ADAPTOR_S 

PRINTS