UniProt Accession

 XGPT_SALTY; P0A277; P26972 

Genbank Protein ID

 X63336; U28239; AE006468 

Genbank Nucleotide ID

 CAA44936.1; AAC01774.1; AAL19273.1 

Protein Name

 Xanthine phosphoribosyltransferase 

Protein Synonyms/Alias

 Xanthine-guanine phosphoribosyltransferase; XGPRT 

Gene Name

 gpt 

Gene Synonyms/Alias

 STM0317 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
30	LMPSEQWKGIIAVSR	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Acts on guanine, xanthine and to a lesser extent hypoxanthine. 

Sequence Annotation

 REGION 37 38 5-phosphoribose 1-diphosphate binding (By
 REGION 92 96 5-phosphoribose 1-diphosphate binding (By
 METAL 89 89 Magnesium (By similarity).
 BINDING 69 69 5-phosphoribose 1-diphosphate (By
 BINDING 92 92 Xanthine (By similarity).
 BINDING 135 135 Xanthine; via amide nitrogen and carbonyl  

Keyword

 Cell inner membrane; Cell membrane; Complete proteome; Glycosyltransferase; Magnesium; Membrane; Metal-binding; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0000310; F:xanthine phosphoribosyltransferase activity; IEA:HAMAP.
 GO:0006166; P:purine ribonucleoside salvage; IEA:HAMAP.
 GO:0032265; P:XMP salvage; IEA:UniProtKB-UniPathway. 

Interpro

 IPR000836; PRibTrfase_dom.
 IPR023747; Xanthine_Guanine_PRibTrfase. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS