CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016152
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Negative elongation factor A 
Protein Synonyms/Alias
  
Gene Name
 Nelf-A 
Gene Synonyms/Alias
 CG5874 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
453IIVPASIKLEKIETSacetylation[1]
1090QQILVQHKPAPTLQQacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. Has an essential role in postembryonic development. 
Sequence Annotation
 DOMAIN 192 249 HDAg-like.  
Keyword
 Chromosome; Complete proteome; Developmental protein; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1251 AA 
Protein Sequence
MANVRDSDTS LWLHNKLGTS NDSWINGSIC SQLNKEVLRN IKECFPDLQT QVKLKLLLSF 60
LHIPRRLVEE WKAELEEVIE VAGLDSELWV SMLAETMKTF PATSSLNTEI SDYEDTRPIF 120
IDMVNDLRKL VTKHSDLGML PLECQYLNKN ALISVVGQQP APVKHFTLKR KPKSAQLRTE 180
LLHKSADAQS SLKKASAPTI PLRSRGMPRK MTDTTPLKGI PSRMPTTGFR SATVPGNAAQ 240
RPNLSRTPAG RKDGGIKLIE FTEQPLGYAA AKKRKREQQL EEQQKKQEQK QQQAAAAAAA 300
AATAAASNAG DSSPTDAATA SGGETPVTPT SANNSFEIKM EPQQLNQSAG SLEEPQDDEM 360
SGKANMECDI ETPEYATATL DFAQATSTSV ADGQPGKPAV ETKLKTPRTP KSAAKLNNNN 420
NNNNNNSFNH TPKRIKQEIE IKSEEIIVPA SIKLEKIETS PSTQRVSIQQ QPPSLVQRTP 480
HLLIRSSPQK RQNNGATTSA GTTTTTVGNT TIKMEKLDIK PMIRATGVSP STSAGTTTTL 540
LTPQQLRQAA NPLANLPNNI SVKITSAKAK AAAAAAATSS GSQTQSQQPQ TLQVQQAPQQ 600
SHPPLLINSS TPVILASSPS AQRAKALALP SSSTSATTTT TIPSQAIKTM PLSQLKTATN 660
SGPVIISQTI IQPAKRAQQQ AGTSSAAAAS QQQQQQQSQQ QLLHQQIQQQ TQQQAQLPQQ 720
PQQQQTQYIL ATPQQQPQQI QQQQQQQQPI LPTLTSFSHS RPMPQTTTLY QATTPSGSGQ 780
TPTKILLKTS GSSSVVMTPL RQAQPQQATA VVSSNPPPLV ATSAAVVSPG QTTLNIQNVQ 840
LPNRPVTIQP ASQAAQQQHM QAQLQQQQPH PQHTIVANTT ATQQPKLSQV LMQPTAAVGT 900
SGVSALNVSP TSGKNKTIIL TQKGVILRNI GGDMYQQIPI SNVGNMQGLG GTTLMTTTAG 960
PPSLVKTTPS SGVQLQQQQS GKQILPTLIP TSSLGGQHVI VQQQQPTNVI GNSQQQTIIR 1020
PVMTNVGGGL TTLPQGLTLI QRPGQQPQLV QVQAAPGSTQ RTIITQSNTA AAASQQQPRQ 1080
QQQQILVQHK PAPTLQQRLV TSTTSGGQGQ QGNPNAGLPR TVQVQVQAQQ QQQPQQQQAT 1140
QQQSQQAPQR RGLSLSNEHV HKAHEMFRKA NRVSRPDKAL ILGFMAGLRE NPRPNNENVL 1200
VIKLGETEEK VQQDNGHTAL CLVESHIRLD YNTGEWKTFQ NYRLQDQSAA S 1251 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0032021; C:NELF complex; IPI:FlyBase.
 GO:0017053; C:transcriptional repressor complex; ISS:UniProtKB.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IDA:FlyBase.
 GO:0007070; P:negative regulation of transcription from RNA polymerase II promoter during mitosis; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR026305; NELF-A. 
Pfam
  
SMART
  
PROSITE
  
PRINTS