CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028851
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Receptor-type tyrosine-protein phosphatase eta 
Protein Synonyms/Alias
  
Gene Name
 Ptprj 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
841EVSFSQIKPKKSKLIubiquitination[1]
858ENFEAYFKKQQADSNubiquitination[1]
859NFEAYFKKQQADSNCubiquitination[1]
1012TIRDFVVKNMQNSESubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1164 AA 
Protein Sequence
MESNLTFPVK NQTSCNITGL SPGTSYTFSI ISVTTNETLN KTITTEPWPV SDLHVTSVGV 60
TQARLTWSNA NGTASYRMLI EELTTHSSVN ISGLKPGTNN SFAFPESNET QADFAVAEEV 120
PDANGTKRIP VTNLSQLHKN SLVSVDPPSG QDPSLTEILL TDLKPDTQYN ATIYSQAANG 180
TEGQPRNKVF KTNSTQVSDV RAMNISASSM TLTWKSNYDG SRTSIVYKIH VAGGTHSVNQ 240
TVNKTEAIIL GLSSSTLYNI TVHPFLGQTE GTPGFLQVYT SPDQVSDFRV TNVSTRAIGL 300
AWRSNDSKSF EIFIKQDGGE KHRNASTGNQ SYMVEDLKPG TSYHFEIIPR GPDGTEGLSS 360
TVNGSTDPSA VTDIRVVNIS TTEMQLEWQN TDDASGYTYH LVLESKSGSI IRTNSSQKWI 420
TVGSLTPGTL YNVTIFPEVD QIQGISNSIT QYTRPSSVSH IEVNTTTTTA AIRWKNEDAA 480
SASYAYSVLI LKTGDGSNVT SNFTKDPSIL IPELIPGVSY TVKILTQVGD GTTSLVPGWN 540
LFCTEPEPVT SFHCEVVPKE PALVLKWACP FGMYTGFELG VRSDSWDNMT RLENCTSDDD 600
TECRTEVAYL NFSTSYNISI ATLSCGKMAL PAQNICTTGI TDPPTPDGSP NITSVSHNSV 660
KVKFSGFEAS HGPIKAYAVI LTTGEAAQPS ADVLKYTYED FKRGASDTYV TYLIRIEEKG 720
QSQGLSEVLN YEIDVGNQST TLGYYNGRLE PLGSYRACVA GFTNITYNLQ NDGLINGDES 780
YVSFSPYSEA VFLPQDPGVI CGAVFGCIFG ALAITAVGGF IFWRKKRTDA KNNEVSFSQI 840
KPKKSKLIRV ENFEAYFKKQ QADSNCGFAE EYEDLKLIGI SLPKYTAEIA ENRGKNRYNN 900
VLPYDISRVK LSVQTHSTDD YINANYMPGY HSKKDFIATQ GPLPNTLKDF WRMVWEKNVY 960
AIVMLTKCVE QGRTKCEEYW PSKQAQDYGD ITVAMTSEVV LPEWTIRDFV VKNMQNSESH 1020
PLRQFHFTSW PDHGVPDTTD LLINFRYLVR DYMKQIPPES PILVHCSAGV GRTGTFIAID 1080
RLIYQIENEN TVDVYGIVYD LRMHRPLMVQ TEDQYVFLNQ CVLDIIRAQK DSKVDLIYQN 1140
TTAMTIYENL EPVSMFGKTN GYIA 1164 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:Compara.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IEA:Compara.
 GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0043116; P:negative regulation of vascular permeability; IEA:Compara.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0050918; P:positive chemotaxis; IEA:Compara.
 GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0001570; P:vasculogenesis; IMP:MGI. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00041; fn3
 PF00102; Y_phosphatase 
SMART
 SM00060; FN3
 SM00194; PTPc 
PROSITE
 PS50853; FN3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.